Site-Specific Clinical Evaluation of the Luminex xTAG Gastrointestinal Pathogen Panel for Detection of Infectious Gastroenteritis in Fecal Specimens

被引：42
作者：
Patel, Anami [1 ]
Navidad, Jose [2 ]
Bhattacharyya, Sanjib [2 ]
机构：
[1] Le Bonheur Childrens Hosp, Memphis, TN USA
[2] City Milwaukee Hlth Dept Lab, Milwaukee, WI 53202 USA
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2014年 / 52卷 / 08期
关键词：
UNITED-STATES; TIME; PCR; QUANTIFICATION; OUTBREAKS; BACTERIA; VIRUSES; IMPACT; ASSAY;
D O I：
10.1128/JCM.01393-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We evaluate the clinical performance of the Luminex xTAG gastrointestinal (GI) pathogen in vitro diagnostic (IVD) assay in a comparison between clinical and public health laboratories. The site reproducibility study showed 98.7% sensitivity with high positive and negative agreement values (96.2% and 99.8%, respectively), while assay performance against confirmatory methods resulted in 96.4% sensitivity with similar positive and negative agreement values (90.1% and 99.5%, respectively). High-throughput detection of multiple GI pathogens improved turnaround time, consolidated laboratory workflow, and simplified stool culture practices, thus reducing the overall cost and number of specimens processed.
引用
收藏
页码：3068 / 3071
页数：4
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