Formation of Methylene Linkage for N-Heterocycles: Sequential C-H and C-O Bond Functionalization of Methanol with Cosolvent Water

被引：17
作者：
Li, Na [1 ]
Bai, Jinku [1 ]
Zheng, Xiaolin [1 ]
Rao, Honghua [1 ,2 ]
机构：
[1] Capital Normal Univ, Dept Chem, Beijing 100048, Peoples R China
[2] Tsinghua Univ, Dept Chem, Minist Educ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2019年 / 84卷 / 11期
基金：
北京市自然科学基金;
关键词：
METAL-CATALYZED REACTIONS; ONE-POT; BORROWING HYDROGEN; BENZYLIC ALCOHOLS; ALLYLIC ALCOHOLS; ALKYLATION; PALLADIUM; EFFICIENT; AMINES; HYDROXYMETHYLATION;
D O I：
10.1021/acs.joc.9b00729
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An iron-catalyzed methylene forming strategy is disclosed through sequential C-H and C-O bond functionalization of methanol with cosolvent water. This protocol provides an easy and novel access to methylene-tethered imidazo[1,2-a]pyridine and 2-aminopyridine analogues in a sustainable manner and represents a complementary approach to traditional methylene forming strategies.
引用
收藏
页码：6928 / 6939
页数：12
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