tRNA - the golden standard in molecular biology

被引：21

作者：

Barciszewska, Miroslawa Z. ^{[1
]}

Perrigue, Patrick M. ^{[1
]}

Barciszewski, Jan ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Bioorgan Chem, PL-61704 Poznan, Poland

来源：

MOLECULAR BIOSYSTEMS | 2016年 / 12卷 / 01期

关键词：

PHENYLALANINE TRANSFER-RNA; SOLUBLE RIBONUCLEIC ACID; ANGSTROM RESOLUTION; PROTEIN SYNTHESIS; CRYSTAL-STRUCTURE; GENETIC-CODE; AMINO ACIDS; YEAST; ACTIVATION; SEQUENCE;

D O I：

10.1039/c5mb00557d

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transfer RNAs (tRNAs) represent a major class of RNA molecules. Their primary function is to help decode a messenger RNA (mRNA) sequence in order to synthesize protein and thus ensures the precise translation of genetic information that is imprinted in DNA. The discovery of tRNA in the late 1950's provided critical insight into a genetic machinery when little was known about the central dogma of molecular biology. In 1965, Robert Holley determined the first nucleotide sequence of alanine transfer RNA (tRNA(Ala)) which earned him the 1968 Nobel Prize in Physiology or Medicine. Today, tRNA is one of the best described and characterized biological molecules. Here we review some of the key historical events in tRNA research which led to breakthrough discoveries and new developments in molecular biology.

引用

页码：12 / 17

页数：6

共 52 条

[1] Transfer RNA and human disease [J].

Abbott, Jamie A. ;

Francklyn, Christopher S. ;

Robey-Bond, Susan M. .

FRONTIERS IN GENETICS, 2014, 5

[2]

BAEV AA, 1967, DOKL AKAD NAUK SSSR+, V173, P204

[3]

BERG P, 1956, J BIOL CHEM, V222, P1025

[4] MODIFICATION OF NUCLEIC-ACIDS IN RELATION TO DIFFERENTIATION [J].

BOREK, E .

TRENDS IN BIOCHEMICAL SCIENCES, 1977, 2 (01) :3-6

[5] GtRNAdb: a database of transfer RNA genes detected in genomic sequence [J].

Chan, Patricia P. ;

Lowe, Todd M. .

NUCLEIC ACIDS RESEARCH, 2009, 37 :D93-D97

[6] ORIGIN OF GENETIC CODE [J].

CRICK, FHC .

JOURNAL OF MOLECULAR BIOLOGY, 1968, 38 (03) :367-&

[7] THE ENZYMATIC ACTIVATION OF AMINO ACIDS VIA THEIR ACYL-ADENYLATE DERIVATIVES [J].

DEMOSS, JA ;

GENUTH, SM ;

NOVELLI, GD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1956, 42 (06) :325-332

[8] Role of tRNA modifications in human diseases [J].

Gabriel Torres, Adrian ;

Batlle, Eduard ;

Ribas de Pouplana, Lluis .

TRENDS IN MOLECULAR MEDICINE, 2014, 20 (06) :306-314

[9] The early history of tRNA recognition by aminoacyl-tRNA synthetases [J].

Giege, Richard .

JOURNAL OF BIOSCIENCES, 2006, 31 (04) :477-488

[10] Structure of transfer RNAs: similarity and variability [J].

Giege, Richard ;

Juehling, Frank ;

Puetz, Joern ;

Stadler, Peter ;

Sauter, Claude ;

Florentz, Catherine .

WILEY INTERDISCIPLINARY REVIEWS-RNA, 2012, 3 (01) :37-61

← 1 2 3 4 5 6 →