Proteomics of Bordetella pertussis whole-cell and acellular vaccines

被引：5

作者：

Moeller, Jens ^{[1
]}

Kraner, Max Edmund ^{[2
]}

Burkovski, Andreas ^{[1
]}

机构：

[1] Friedrich Alexander Univ Erlangen Nurnberg, Staudtstr 5, D-91058 Erlangen, Germany

[2] Friedrich Alexander Univ Erlangen Nurnberg, Lehrstuhl Biochem, Erlangen, Germany

来源：

BMC RESEARCH NOTES | 2019年 / 12卷 / 1期

关键词：

Bordetella; DTP vaccine; LC-MS; MS; Mass spectrometry; Pertussis; Vaccination; Whooping cough;

D O I：

10.1186/s13104-019-4373-2

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

ObjectivesBordetella pertussis is the etiological agent of whooping cough, a bacterial infection of especially children, which may be fatal without treatment. In frame of studies to investigate putative effects of vaccination on host-pathogen interaction and clonal distribution of strains, in addition to Corynebacterium diphtheriae and Clostridium tetani toxoid vaccines, also whole-cell and acellular pertussis vaccines were analyzed by mass spectrometry.Data descriptionLC-MS/MS spectra were generated and analyzed using B. pertussis genome data and proteins present in whole-cell and acellular pertussis vaccines were identified. Subcellular localization of proteins and presence of signal peptides was determined bioinformatically.

引用

页数：3

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