Pathology of childhood rhabdomyosarcoma: A consensus opinion document from the Children's Oncology Group, European Paediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe

被引：43

作者：

Rudzinski, Erin R. ^{[1
]}

Kelsey, Anna ^{[2
]}

Vokuhl, Christian ^{[3
]}

Linardic, Corinne M. ^{[4
,5
]}

Shipley, Janet ^{[6
,7
]}

Hettmer, Simone ^{[8
]}

Koscielniak, Ewa ^{[9
]}

Hawkins, Douglas S. ^{[10
,11
]}

Bisogno, Gianni ^{[12
]}

机构：

[1] Seattle Childrens Hosp, Dept Labs, Seattle, WA 98105 USA

[2] Royal Manchester Childrens Hosp Manchester Fdn Tr, Dept Paediat Histopathol, Manchester, Lancs, England

[3] Univ Hosp Bonn, Dept Pathol, Sect Pediat Pathol, Bonn, Germany

[4] Duke Univ, Sch Med, Dept Pediat, Durham, NC USA

[5] Duke Univ, Sch Med, Dept Pharmacol & Canc Biol, Durham, NC USA

[6] Inst Canc Res, Sarcoma Mol Pathol Team, Div Mol Pathol, London, England

[7] Inst Canc Res, Sarcoma Mol Pathol Team, Div Canc Therapeut, London, England

[8] Univ Freiburg, Div Pediat Hematol & Oncol, Dept Pediat & Adolescent Med, Univ Med Ctr Freiburg, Freiburg, Germany

[9] Klinikum Stuttgart, Olgahosp, Pediat Oncol Hematol Immunol 5, Stuttgart, Germany

[10] Univ Washington, Sch Med, Seattle Childrens Hosp, Canc & Blood Disorders Ctr, Seattle, WA USA

[11] Univ Washington, Sch Med, Dept Pediat, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA

[12] Univ Padua, Dipartimento Salute Donna & Bambino, Padua, Italy

来源：

PEDIATRIC BLOOD & CANCER | 2021年 / 68卷 / 03期

关键词：

pathology; pediatric; rhabdomyosarcoma; ALVEOLAR RHABDOMYOSARCOMA; FUSION STATUS; SCLEROSING RHABDOMYOSARCOMA; GENE; CLASSIFICATION; SPINDLE; COMMITTEE; AP2-BETA; MYOGENIN; TUMORS;

D O I：

10.1002/pbc.28798

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The diagnosis and classification of rhabdomyosarcoma (RMS) has undergone several shifts over the last 30 years. While the main diagnostic categories remained the same, changes in the histologic criteria necessary for diagnosis, as well as varied reliance on immunohistochemical and molecular data over time, have created confusion, particularly regarding how these shifts impacted risk stratification and enrollment onto clinical trials. The goal of this report is to review the evolution and current status of RMS diagnosis, focusing on diagnostic criteria in the Children's Oncology Group (COG), the European Paediatric Soft Tissue Sarcoma Group (EpSSG), and the Cooperative Weichteilsarkom Studiengruppe (CWS). In addition, we emphasize research tools used to classify RMS and address biological questions within current clinical trials run by each group. The INternational Soft Tissue SaRcoma ConsorTium (INSTRuCT) initiative will maximize potential to optimize risk stratification by recognizing and accounting for differences in historical data and current practices.

引用

页数：10

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