Developing an international Pseudomonas aeruginosa reference panel

被引：92

作者：

De Soyza, Anthony ^{[1
]}

Hall, Amanda J. ^{[2
]}

Mahenthiralingam, Eshwar ^{[3
]}

Drevinek, Pavel ^{[4
,5
]}

Kaca, Wieslaw ^{[6
]}

Drulis-Kawa, Zuzanna ^{[7
]}

Stoitsova, Stoyanka R. ^{[8
]}

Toth, Veronika ^{[9
]}

Coenye, Tom ^{[10
]}

Zlosnik, James E. A. ^{[11
]}

Burns, Jane L. ^{[12
]}

Sa-Correia, Isabel ^{[13
]}

De Vos, Daniel ^{[14
]}

Pirnay, Jean-Paul ^{[14
]}

Kidd, Timothy J. ^{[15
]}

Reid, David ^{[16
]}

Manos, Jim ^{[17
]}

Klockgether, Jens ^{[18
]}

Wiehlmann, Lutz ^{[18
]}

Tuemmler, Burkhard ^{[18
]}

McClean, Siobhan ^{[19
]}

Winstanley, Craig ^{[2
]}

机构：

[1] Newcastle Univ, Inst Cellular Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[2] Univ Liverpool, Inst Infect & Global Hlth, Liverpool L69 3BX, Merseyside, England

[3] Cardiff Univ, Cardiff Sch Biosci, Organisms & Environm Div, Cardiff CF10 3AX, S Glam, Wales

[4] Charles Univ Prague, Dept Med Microbiol, Fac Med 2, Prague, Czech Republic

[5] Univ Hosp Motol, Prague, Czech Republic

[6] Jan Kochanowski Univ, Kielce, Poland

[7] Univ Wroclaw, Inst Genet & Microbiol, PL-50138 Wroclaw, Poland

[8] Stephan Angeloff Inst Microbiol, Sofia, Bulgaria

[9] Semmelweis Univ, H-1085 Budapest, Hungary

[10] Univ Ghent, Ghent, Belgium

[11] Univ British Columbia, Fac Med, Dept Pediat, Ctr Understanding & Preventing Infect Children, Vancouver, BC, Canada

[12] Seattle Childrens Hosp, Seattle, WA USA

[13] Univ Lisbon, Inst Super Tecn, CEBQ, IBB, P-1699 Lisbon, Portugal

[14] Queen Astrid Mil Hosp, Brussels, Belgium

[15] Univ Queensland, Queensland Childrens Med Res Inst, Brisbane, Qld, Australia

[16] Prince Charles Hosp, Brisbane, Qld 4032, Australia

[17] Univ Sydney, Sydney Med Sch, Dept Infect Dis & Immunol, Sydney, NSW 2006, Australia

[18] Hannover Med Sch, Hannover, Germany

[19] Inst Technol, Ctr Microbial Host Interact, Tallaght, Ireland

来源：

MICROBIOLOGYOPEN | 2013年 / 2卷 / 06期

基金：

美国国家卫生研究院;

关键词：

Cystic fibrosis; genotype; pathogen; Pseudomonas aeruginosa; FIBROSIS EPIDEMIC STRAIN; CYSTIC-FIBROSIS; GENOME DIVERSITY; TRANSMISSIBLE STRAINS; POPULATION-STRUCTURE; ENHANCED VIRULENCE; CLINICAL-OUTCOMES; CLONAL STRAIN; SEQUENCE; IDENTIFICATION;

D O I：

10.1002/mbo3.141

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pseudomonas aeruginosa is a major opportunistic pathogen in cystic fibrosis (CF) patients and causes a wide range of infections among other susceptible populations. Its inherent resistance to many antimicrobials also makes it difficult to treat infections with this pathogen. Recent evidence has highlighted the diversity of this species, yet despite this, the majority of studies on virulence and pathogenesis focus on a small number of strains. There is a pressing need for a P. aeruginosa reference panel to harmonize and coordinate the collective efforts of the P. aeruginosa research community. We have collated a panel of 43 P. aeruginosa strains that reflects the organism's diversity. In addition to the commonly studied clones, this panel includes transmissible strains, sequential CF isolates, strains with specific virulence characteristics, and strains that represent serotype, genotype or geographic diversity. This focussed panel of P. aeruginosa isolates will help accelerate and consolidate the discovery of virulence determinants, improve our understanding of the pathogenesis of infections caused by this pathogen, and provide the community with a valuable resource for the testing of novel therapeutic agents.

引用

页码：1010 / 1023

页数：14

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