Biological Evaluation and 3D-QSAR Studies of Curcumin Analogues as Aldehyde Dehydrogenase 1 Inhibitors

被引：7
作者：
Wang, Hui [1 ]
Du, Zhiyun [1 ]
Zhang, Changyuan [1 ]
Tang, Zhikai [1 ,2 ]
He, Yan [1 ]
Zhang, Qiuyan [1 ]
Zhao, Jun [1 ,3 ]
Zheng, Xi [1 ,3 ]
机构：
[1] Guangdong Univ Technol, Sch Light Ind & Chem Engn, Guangzhou 510500, Guangdong, Peoples R China
[2] Guangzhou Improve Med Technol Co Ltd, Guangzhou 510530, Guangdong, Peoples R China
[3] Rutgers State Univ, Ernest Mario Sch Pharm, Susan Lehman Cullman Lab Canc Res, Piscataway, NJ 08854 USA
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 05期
基金：
中国博士后科学基金; 中国国家自然科学基金;
关键词：
curcumin; curcumin analogues; ALDH1; inhibitor; 3D-QSAR; L1210; CELLS; 4-HYDROPEROXYCYCLOPHOSPHAMIDE; ANTAGONISTS; APOPTOSIS; DOCKING;
D O I：
10.3390/ijms15058795
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aldehyde dehydrogenase 1 (ALDH1) is reported as a biomarker for identifying some cancer stem cells, and down-regulation or inhibition of the enzyme can be effective in anti-drug resistance and a potent therapeutic for some tumours. In this paper, the inhibitory activity, mechanism mode, molecular docking and 3D-QSAR (three-dimensional quantitative structure activity relationship) of curcumin analogues (CAs) against ALDH1 were studied. Results demonstrated that curcumin and CAs possessed potent inhibitory activity against ALDH1, and the CAs compound with ortho di-hydroxyl groups showed the most potent inhibitory activity. This study indicates that CAs may represent a new class of ALDH1 inhibitor.
引用
收藏
页码：8795 / 8807
页数：13
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