RNA seeing double: Close-packing of helices in RNA tertiary structure

被引：40
|
作者：
Strobel, SA
Doudna, JA
机构：
[1] Dept. Molec. Biophys. and Biochem., Yale University, 260 Whitney Avenue, New Haven
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1997年 / 22卷 / 07期
关键词：
D O I：
10.1016/S0968-0004(97)01056-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Structured RNA molecules play essential roles in RNA processing, chromosome maintenance and protein biosynthesis. RNA necessarily uses different strategies than proteins for folding and assembly of complex architectures. The RNA-folding problem is largely an issue of helical packing: how does RNA organize and pack short, double-helical segments to produce active sites and recognition motifs for proteins? Noncanonical base pairs, metal ions and 2'-hydroxyl groups are key elements in RNA higher-order structure formation.
引用
收藏
页码：262 / 266
页数：5
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