The Hippo signaling pathway in stem cell biology and cancer

被引：586
作者：
Mo, Jung-Soon
Park, Hyun Woo
Guan, Kun-Liang [1 ]
机构：
[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA
来源：
EMBO REPORTS | 2014年 / 15卷 / 06期
基金：
美国国家卫生研究院;
关键词：
cancer; Hippo pathway; regeneration; stem cell; YAP; TUMOR-SUPPRESSOR PATHWAY; YES-ASSOCIATED PROTEIN; SELF-RENEWAL; TISSUE-GROWTH; CARDIOMYOCYTE PROLIFERATION; PROMOTES APOPTOSIS; YAP ONCOPROTEIN; ORGAN SIZE; MAMMALIAN DEVELOPMENT; NUCLEAR-LOCALIZATION;
D O I：
10.15252/embr.201438638
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and downstream transcription co-activators (YAP and TAZ), plays a key role in tissue homeostasis and organ size control by regulating tissue-specific stem cells. Moreover, this pathway plays a prominent role in tissue repair and regeneration. Dysregulation of the Hippo pathway is associated with cancer development. Recent studies have revealed a complex network of upstream inputs, including cell density, mechanical sensation, and G-protein-coupled receptor (GPCR) signaling, that modulate Hippo pathway activity. This review focuses on the role of the Hippo pathway in stem cell biology and its potential implications in tissue homeostasis and cancer.
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收藏
页码：642 / 656
页数：15
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