Role of toll-like receptors gene polymorphism in renal transplantation

Toll-like receptors (TLRs), evolutionarily conserved innate, are expressed in a wide variety of tissues and cell types, and they play key role in the innate immune system. Gene mutation is an important factor associated with some diseases risk and gene polymorphism of TLRs can influence their function to take part in the physiological process in the body. Chronic kidney disease causes high morbidity and mortality, and renal transplantation provides the optimal treatment for people with end-stage renal disease. Innate immune takes a most important role in renal transplantation. There are some studies reporting that TLRs gene polymorphism takes an important role in the renal transplantation. However, no review summed up the role of TLRs gene polymorphism in renal transplantation. The literatures were searched extensively and this review was performed to review the role of TLRs gene polymorphism in renal transplantation.