Shortwave Infrared Imaging with J-Aggregates Stabilized in Hollow Mesoporous Silica Nanoparticles

被引：160

作者：

Chen, Wei ^{[1
,3
]}

Cheng, Chi-An ^{[2
,3
]}

Cosco, Emily D. ^{[1
,4
]}

Ramakrishnan, Shyam ^{[4
]}

Lingg, Jakob G. P. ^{[4
]}

Bruns, Oliver T. ^{[4
]}

Zink, Jeffrey I. ^{[1
,3
]}

Sletten, Ellen M. ^{[1
,3
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biochem, 607 Charles E Young Dr East, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Bioengn, 607 Charles E Young Dr East, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Calif NanoSyst Inst, 607 Charles E Young Dr East, Los Angeles, CA 90095 USA

[4] Helmholtz Zentrum Munchen, Helmholtz Pioneer Campu, D-85764 Neuherberg, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2019年 / 141卷 / 32期

关键词：

DRUG-DELIVERY; QUANTUM DOTS; FLUORESCENCE; NANOMACHINES; NANOSPHERES; ABSORPTION; PRINCIPLES; STIMULI; DESIGN;

D O I：

10.1021/jacs.9b05195

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tissue is translucent to shortwave infrared (SWIR) light, rendering optical imaging superior in this region. However, the widespread use of optical SWIR imaging has been limited, in part, by the lack of bright, biocompatible contrast agents that absorb and emit light above 1000 nm. J-Aggregation offers a means to transform stable, near-infrared (NJR) fluorophores into red-shifted SWIR contrast agents. Here we demonstrate that J-aggregates of NIR fluorophore IR-140 can be prepared inside hollow mesoporous silica nanoparticles (HMSNs) to result in nanomaterials that absorb and emit SWIR light. The J-aggregates inside PEGylated HMSNs are stable for multiple weeks in buffer and enable high resolution imaging in vivo with 980 nm excitation.

引用

页码：12475 / 12480

页数：6

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