Blood lipid levels, statin therapy and the risk of intracerebral hemorrhage

被引：22
作者：
Ma, Yingxu [1 ,2 ]
Li, Zhaokai [1 ,2 ]
Chen, Liang [1 ,2 ]
Li, Xiangping [1 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Cardiol, 139 Middle Renmin Rd, Changsha 410011, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Sch Med, Year Clin Med Grade 2012 8, Changsha 410013, Hunan, Peoples R China
来源：
LIPIDS IN HEALTH AND DISEASE | 2016年 / 15卷
关键词：
Lipids; Statin; Lipid-lowering therapy; Intracerebral hemorrhage; STROKE PREVENTION; TOTAL CHOLESTEROL; VASCULAR EVENTS; HOSPITALIZATION; ATORVASTATIN; ASSOCIATION; MODELS; AKITA;
D O I：
10.1186/s12944-016-0213-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Dyslipidemia has been proven to play an important role in the occurrence and development of the ischemic stroke and lipid-lowering therapy could significantly decrease the risk of the ischemic stroke. However, the association between lipid levels, lipid-lowering therapy and the risk of intracerebral hemorrhage (ICH) is not clear. Studies have shown that low serum levels of total cholesterol might be associated with increasing risk of ICH, whereas the SPARCL study, a large prospective, randomized, placebo-controlled trial, demonstrated an increased risk of hemorrhagic stroke during high-dose statin therapy among the patients with previous stroke. The relationship between lipid-lowering therapy and ICH has become a hot topic in the recent years. We searched PubMed for articles published in English to review the existing evidence on the association of lipid levels, statin therapy and risk of ICH as well as the underlying mechanisms in order to provide practical recommendations for clinical decision-making and a foundation for further researches.
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页数：9
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