Defined drug release from 3D-printed composite tablets consisting of drugloaded polyvinylalcohol and a water-soluble or water-insoluble polymer filler

被引：83

作者：

Tagami, Tatsuaki ^{[1
]}

Nagata, Noriko ^{[1
]}

Hayashi, Naomi ^{[1
]}

Ogawa, Emi ^{[1
]}

Fukushige, Kaori ^{[1
,3
]}

Sakai, Norihito ^{[2
]}

Ozeki, Tetsuya ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Drug Delivery & Nano Pharmaceut, Mizuho Ku, 3-1 Tanabe Dori, Nagoya, Aichi 4678603, Japan

[2] Nippon Synthet Chem Ind Co Ltd, Kita Ku, 2-4 Komatsubara Cho, Osaka 5300018, Japan

[3] Aichi Med Univ, Dept Anat, 1-1 Yazakokarimata, Nagakute, Aichi 4801195, Japan

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2018年 / 543卷 / 1-2期

关键词：

Composite tablet; Controlled release; Fused deposition modeling (FDM)-type 3D; printer; Polylactic acid (PLA); Polyvinylalcohol (PVA); 3D-printed therapeutic drug; DELIVERY-SYSTEMS; 3D; FABRICATION; IMMEDIATE; DEVICES;

D O I：

10.1016/j.ijpharm.2018.03.057

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

3D-printed tablets are a promising new approach for personalized medicine. In this study, we fabricated composite tablets consisting of two components, a drug and a filler, by using a fused deposition modeling-type 3D printer. Polyvinylalcohol (PVA) polymer containing calcein (a model drug) was used as the drug component and PVA or polylactic acid (PLA) polymer without drug was used as the water-soluble or water-insoluble filler, respectively. Various kinds of drug-PVA/PVA and drug-PVA/PLA composite tablets were designed, and the 3Dprinted tablets exhibited good formability. The surface area of the exposed drug component is highly correlated with the initial drug release rate. Composite tablets with an exposed top and a bottom covered with a PLA layer were fabricated. These tablets showed zero-order drug release by maintaining the surface area of the exposed drug component during drug dissolution. In contrast, the drug release profile varied for tablets whose exposed surface area changed. Composite tablets with different drug release lag times were prepared by changing the thickness of the PVA filler coating the drug component. These results which used PVA and PLA filler will provide useful information for preparing the tablets with multi-components and tailor-made tablets with defined drug release profiles using 3D printers.

引用

页码：361 / 367

页数：7

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