Age-related macular degeneration: An immunologically driven disease

被引：0
作者：
Nussenblatt, Robert B. [1 ]
Liu, Baoying [1 ]
Li, Zhuqing [1 ]
机构：
[1] NEI, NIH, Immunol Lab, Bethesda, MD 20892 USA
来源：
CURRENT OPINION IN INVESTIGATIONAL DRUGS | 2009年 / 10卷 / 05期
关键词：
Age-related macular degeneration; AMD; immune response; intraocular inflammatory disease; COMPLEMENT FACTOR-H; C-REACTIVE PROTEIN; CHOROIDAL NEOVASCULARIZATION; MACROPHAGE ACTIVATION; IMMUNE-RESPONSE; BRUCHS MEMBRANE; DRUSEN; POLYMORPHISM; MACULOPATHY; MONOCYTE;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in elderly individuals worldwide. Genome-wide association studies have provided evidence that the immune system is involved in the pathogenesis of AMD. This review discusses historical and more recent studies that have led to the recognition that AMD is an intraocular inflammatory disease, and that is possibly driven by an immune response. A particular focus of this review is recent studies on the contribution of the complement system and macrophages to the pathogenesis of AMD. A working hypothesis is also presented that may reconcile the current understanding of the pathogenesis of AMD and some apparently contradictory findings in the literature.
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收藏
页码：434 / 442
页数：9
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