Risk Stratification for Primary Prevention of Coronary Artery Disease: Roles of C-Reactive Protein and Coronary Artery Calcium

被引：19
|
作者：
Qureshi, Waqas T. [1 ]
Rana, Jamal S. [2 ,3 ,5 ]
Yeboah, Joseph [1 ]
bin Nasir, Usama [1 ]
Al-Mallah, Mouaz H. [4 ,6 ]
机构：
[1] Wake Forest Univ, Sch Med, Dept Internal Med, Div Cardiovasc Med, Winston Salem, NC 27157 USA
[2] Kaiser Permanente No Calif, Div Cardiol, Oakland, CA 94609 USA
[3] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
[4] King Abdul Aziz Cardiac Ctr, Cardiac Imaging, Riyadh, Saudi Arabia
[5] Kaiser Permanente No Calif, Div Res, Oakland, CA 94609 USA
[6] King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia
来源：
CURRENT CARDIOLOGY REPORTS | 2015年 / 17卷 / 12期
关键词：
Statin therapy; Cholesterol treatment; High sensitivity C reactive protein; Coronary artery calcium; Risk factors; Epidemiology; Review; BEAM COMPUTED-TOMOGRAPHY; ALL-CAUSE MORTALITY; CARDIOVASCULAR-DISEASE; HEART-DISEASE; SYMPTOMATIC PATIENTS; PROGNOSTIC VALUE; ATHEROSCLEROTIC LESIONS; ASYMPTOMATIC PATIENTS; AMERICAN-COLLEGE; PREDICTIVE-VALUE;
D O I：
10.1007/s11886-015-0666-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Risk stratification of individuals at risk for atherosclerotic cardiovascular disease (ASCVD) plays an important role in primary prevention of cardiovascular disease. In addition to risk scores derived from conventional cardiovascular risk factors, high sensitivity C-reactive protein (hs-CRP) and coronary artery calcium (CAC) have emerged as two of the widely accepted non traditional risk factors for atherosclerotic disease that have shown incremental prognostic value in predicting cardiovascular events. This review systematically assesses the role of hs-CRP and CAC in various studies and demonstrates meta-analyses of the incremental prognostic value of hs-CRP and CAC in identifying patients at risk of future CVD events. Compared with this, CAC showed better incremental prognostic value and might be a better indicator of ASCVD risk in asymptomatic adults.
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页数：14
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