Targeting inflammation in the treatment of type 2 diabetes: time to start

被引：570

作者：

Donath, Marc Y. ^{[1
]}

机构：

[1] Univ Basel Hosp, CH-4031 Basel, Switzerland

来源：

NATURE REVIEWS DRUG DISCOVERY | 2014年 / 13卷 / 06期

关键词：

NECROSIS-FACTOR-ALPHA; THIOREDOXIN-INTERACTING PROTEIN; ISLET-ASSOCIATED MACROPHAGES; IMPROVES INSULIN-RESISTANCE; ACTIVATED RECEPTOR-GAMMA; DIET-INDUCED OBESITY; BETA-CELL FAILURE; ADIPOSE-TISSUE; NLRP3; INFLAMMASOME; DOUBLE-BLIND;

D O I：

10.1038/nrd4275

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The role of inflammation in the pathogenesis of type 2 diabetes and associated complications is now well established. Several conditions that are driven by inflammatory processes are also associated with diabetes, including rheumatoid arthritis, gout, psoriasis and Crohn's disease, and various anti-inflammatory drugs have been approved or are in late stages of development for the treatment of these conditions. This Review discusses the rationale for the use of some of these anti-inflammatory treatments in patients with diabetes and what we could expect from their use. Future immunomodulatory treatments may not target a specific disease, but could instead act on a dysfunctional pathway that causes several conditions associated with the metabolic syndrome.

引用

页码：465 / 476

页数：12

共 151 条

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