Preparation of pilot library with tetrahydro-β-carboline alkaloid core skeleton using tandem intramolecular Pictet-Spengler cyclization

被引：19

作者：

Lee, Sung-Chan ^{[1
]}

Choi, Soo Young ^{[1
]}

Chung, Young Keun ^{[1
]}

Park, Seung Bum ^{[1
]}

机构：

[1] Seoul Natl Univ, Dept Chem, Seoul 151747, South Korea

来源：

TETRAHEDRON LETTERS | 2006年 / 47卷 / 38期

关键词：

D O I：

10.1016/j.tetlet.2006.07.051

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A solid phase strategy has been developed for the synthesis of tetrahydro-beta-carboline alkaloid library. The key transformation is an acid-catalyzed tandem intramolecular Pictet-Spengler cyclization from L-tryptophan which forms acyl iminiums with synchronous cleavage of products from the acid-labile SASRIN (TM) solid support. A pilot library with two diversity points has been successfully synthesized in high purity to demonstrate this strategy. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：6843 / 6847

页数：5

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