Synthesis and antiviral evaluation of thieno[3,4-d] pyrimidine C-nucleoside analogues of 2′,3′-dideoxy- and 2′,3′-dideoxy-2′,3′-didehydro-adenosine and -inosine

被引：7

作者：

Hamann, Marie ^{[1
]}

Pierra, Claire ^{[1
]}

Sommadossi, Jean-Pierre ^{[2
]}

Musiu, Chiara ^{[3
]}

Vargiu, Luana ^{[3
]}

Liuzzi, Michel ^{[3
]}

Storer, Richard ^{[1
]}

Gosselin, Gilles ^{[1
]}

机构：

[1] Idenix Pharmaceut, Med Chem Labs IDENIX Sarl, F-34189 Montpellier 4, France

[2] Idenix Pharmaceut, Cambridge, MA 02139 USA

[3] Univ Cagliari, Idenix Pharmaceut, Lab Cooperat Idenix, I-09010 Cagliari, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2009年 / 17卷 / 06期

关键词：

HIV-1; NRTI; 2; 3 '-Dideoxy C-nucleoside analogues; 7,9-Dideaza-8-thiapurine series; Synthesis; Antiviral evaluation; HIV; INHIBITORS; CHEMISTRY;

D O I：

10.1016/j.bmc.2009.02.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Several thieno[3,4-d] pyrimidine derivatives, including four hitherto unknown 2',3'-dideoxy- and 2',3'-dideoxy- 2',3'-didehydro-C-nucleoside analogues of adenosine and inosine have been synthesized. When evaluated in cell culture experiments against human immunodeficiency virus, none of the tested compounds exhibited any significant antiviral effect, while two of them showed some cytotoxicity. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2321 / 2326

页数：6

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