Simple aromatic compounds containing propenone moiety show considerable dual COX/5-LOX inhibitory activities

被引：100
作者：
Jahng, Y
Zhao, LX
Moon, YS
Basnet, A
Kim, EK
Chang, HW [1 ]
Ju, HK
Jeong, TC
Lee, ES
机构：
[1] Yeungnam Univ, Coll Pharm, Kyongsan 712749, South Korea
[2] Liaoning Normal Univ, Dept Chem, Dalian 116029, Liaoning, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
D O I：
10.1016/j.bmcl.2004.02.099
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
For the development of safer anti-inflammatory agents, simple aromatic compounds containing propenone moiety were prepared and evaluated for their dual COX/5-LOX inhibitory activities. Among the 17 prepared compounds, most of the compounds exhibited considerable COX/5-LOX inhibitory activities. Especially compound C-15 showed the most significant dual COX/5-LOX inhibitory activity. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2559 / 2562
页数：4
相关论文
共 29 条
[1]   Dual acting anti-inflammatory drugs: A reappraisal [J].
Bertolini, A ;
Ottani, A ;
Sandrini, M .
PHARMACOLOGICAL RESEARCH, 2001, 44 (06) :437-450
[2]  
Catella-Lawson F, 1999, J PHARMACOL EXP THER, V289, P735
[3]   Anti-inflammatory drugs: New multitarget compounds to face an old problem. The dual inhibition concept [J].
Celotti, F ;
Laufer, S .
PHARMACOLOGICAL RESEARCH, 2001, 43 (05) :429-436
[4]   Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs [J].
Charlier, C ;
Michaux, C .
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2003, 38 (7-8) :645-659
[5]   Prevention of thrombosis and vascular inflammation: benefits and limitations of selective or combined COX-1, COX-2 and 5-LOX inhibitors [J].
de Gaetano, G ;
Donati, MB ;
Cerletti, C .
TRENDS IN PHARMACOLOGICAL SCIENCES, 2003, 24 (05) :245-252
[6]  
DeWitt D L, 1993, Am J Med, V95, p40S, DOI 10.1016/0002-9343(93)90396-7
[7]  
Dyer RD, 1997, CURR PHARM DESIGN, V3, P463
[8]   Dual inhibitors of cyclooxygenase and 5-lipoxygenase. A new avenue in anti-inflammatory therapy? [J].
Fiorucci, S ;
Meli, R ;
Bucci, M ;
Cirino, G .
BIOCHEMICAL PHARMACOLOGY, 2001, 62 (11) :1433-1438
[9]  
Fosslien E, 1998, ANN CLIN LAB SCI, V28, P67
[10]   TOWARD AN EPIDEMIOLOGY OF GASTROPATHY ASSOCIATED WITH NONSTEROIDAL ANTIINFLAMMATORY DRUG-USE [J].
FRIES, JF ;
MILLER, SR ;
SPITZ, PW ;
WILLIAMS, CA ;
HUBERT, HB ;
BLOCH, DA .
GASTROENTEROLOGY, 1989, 96 (02) :647-655
123