Colon cancer cells adhesion on polymeric nanostructured surfaces

被引：6
作者：
Accardo, Angelo [1 ]
Shalabaeva, Victoria [2 ]
La Rocca, Rosanna [2 ]
机构：
[1] Univ Toulouse, LAAS CNRS, CNRS, 7 Ave Colonel Roche, F-31400 Toulouse, France
[2] Ist Italiano Tecnol, Via Morego 30, I-16163 Genoa, Italy
来源：
MRS COMMUNICATIONS | 2018年 / 8卷 / 01期
关键词：
SUPERHYDROPHOBIC SURFACES; PLASMA MODIFICATION; FREE-ENERGY; PMMA FILMS; ATTACHMENT; SCATTERING; FILOPODIA; MICRO; MODEL;
D O I：
10.1557/mrc.2017.128
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In this work, we report on the adhesion of HCT116 (human colon carcinoma cells) cultured on nanofibrillar polymethylmethacrylate (PMMA) and SU-8 micropillars substrates. Both surfaces enabled a good cell proliferation and promoted the formation of adherent interconnections with the fabricated nano- and microstructures. The three-dimensional immunofluorescence confocal characterization of the cells on nanotextured PMMA highlighted the expression of well-spread F-actin cytoskeletal networks as well as the presence of focal adhesions. This study provides thus interesting perspectives for further investigations on the force/adhesion mechanisms related to cancer cell growth and proliferation.
引用
收藏
页码：35 / 39
页数：5
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