Mycobacterial infections in adults with haematological malignancies and haematopoietic stem cell transplants: guidelines from the 8th European Conference on Infections in Leukaemia

被引：37

作者：

Bergeron, Anne ^{[1
,2
]}

Mikulska, Malgorzata ^{[3
,4
]}

De Greef, Julien ^{[5
]}

Bondeelle, Louise ^{[6
]}

Franquet, Tomas ^{[7
]}

Herrmann, Jean-Louis ^{[8
,9
]}

Lange, Christoph ^{[10
,11
,12
,13
,14
]}

Spriet, Isabel ^{[15
]}

Akova, Murat ^{[17
]}

Donnelly, J. Peter ^{[18
]}

Maertens, Johan ^{[16
]}

Maschmeyer, Georg ^{[19
]}

Rovira, Montserrat ^{[20
,21
]}

Goletti, Delia ^{[22
]}

de la Camara, Rafael ^{[23
]}

机构：

[1] Geneva Univ Hosp, Div Pulmonol, CH-1211 Geneva, Switzerland

[2] Univ Paris, INSERM, ECSTRRA Team, Paris, France

[3] Univ Genoa, Dept Hlth Sci, Infect Dis, Genoa, Italy

[4] San Martino Polyclin Hosp, Genoa, Italy

[5] Catholic Univ Louvain, St Luc Univ Clin, Div Internal Med & Infect Dis, Brussels, Belgium

[6] Univ Paris, St Louis Hosp, AP HP, Div Pulmonol, Paris, France

[7] Autonomous Univ Barcelona, St Pau Hosp, Dept Radiol, Barcelona, Spain

[8] GHU Paris Saclay, Microbiol Dept, Raymond Poincare Hosp, Paris, France

[9] Paris Saclay Univ, INSERM, UVSQ, Div Infect & Inflammat, Paris, France

[10] Res Ctr Borstel, Div Clin Infect Dis, Borstel, Germany

[11] TTU TB, German Ctr Infect Res DZIF, Borstel, Germany

[12] Univ Lubeck, Resp Med & Int Hlth, Lubeck, Germany

[13] Baylor Coll Med, Houston, TX 77030 USA

[14] Texas Childrens Hosp, Houston, TX 77030 USA

[15] Univ Leuven, Univ Hosp Leuven, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium

[16] Univ Leuven, Univ Hosp Leuven, Dept Haematol, Leuven, Belgium

[17] Hacettepe Univ, Dept Med, Sect Infect Dis, Med Sch, Ankara, Turkey

[18] Radboudumc, Dept Haematol, Nijmegen, Netherlands

[19] Ernst von Bergmann Clin, Dept Haematol Oncol & Palliat Care, Potsdam, Germany

[20] IDIBAPS, Hosp Clin, Haematol Dept, BMT Unit, Barcelona, Spain

[21] Josep Carreras Fdn, Barcelona, Spain

[22] Lauaro Spallanzani Natl Inst Infect Dis, Dept Epidemiol & Preclin Res, Translat Res Unit, Rome, Italy

[23] Princess Univ Hosp, Haematol Dept, Madrid, Spain

来源：

LANCET INFECTIOUS DISEASES | 2022年 / 22卷 / 12期

关键词：

TUBERCULIN SKIN-TEST; QUANTIFERON-TB GOLD; LATENT TUBERCULOSIS; NONTUBERCULOUS MYCOBACTERIA; ACTIVE TUBERCULOSIS; RISK-FACTORS; PULMONARY TUBERCULOSIS; IMMUNOCOMPROMISED PATIENTS; HICKMAN CATHETER; ADVERSE EVENTS;

D O I：

10.1016/S1473-3099(22)00227-4

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Mycobacterial infections, both tuberculosis and nontuberculous, are more common in patients with haematological malignancies and haematopoietic stem cell transplant recipients than in the general population-although these infections remain rare. Mycobacterial infections pose both diagnostic and therapeutic challenges. The management of mycobacterial infections is particularly complicated for patients in haematology because of the many drug-drug interactions between antimycobacterial drugs and haematological and immunosuppressive treatments. The management of mycobacterial infections must also consider the effect of delaying haematological management. We surveyed the management practices for latent tuberculosis infection (LTBI) in haematology centres in Europe. We then conducted a meticulous review of the literature on the epidemiology, diagnosis, and management of LTBI, tuberculosis, and nontuberculous mycobacterial infections among patients in haematology, and we formulated clinical guidelines according to standardised European Conference on Infections in Leukaemia (ECIL) methods. In this Review, we summarise the available literature and the recommendations of ECIL 8 for managing mycobacterial infections in patients with haematological malignancies.

引用

页码：E359 / E369

页数：11

共 111 条

[1] Impact of type of calcineurin inhibitor on post-transplant tuberculosis: Single-center study from India [J].