In vitro activities of ravuconazole and four other antifungal agents against fluconazole-resistant or -susceptible clinical yeast isolates

被引:41
作者
Cuenca-Estrella, M [1 ]
Gomez-Lopez, A [1 ]
Mellado, E [1 ]
Garcia-Effron, G [1 ]
Rodriguez-Tudela, JL [1 ]
机构
[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Serv Micol, Majadahonda 28220, Madrid, Spain
关键词
D O I
10.1128/AAC.48.8.3107-3111.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The activities of ravuconazole and four other antifungal agents were tested against a collection of 1,796 clinical yeast isolates, including fluconazole-susceptible and -resistant strains. Ravuconazole was active against the majority of fluconazole-resistant isolates; but for 102 of 562 (18%) resistant isolates, mainly Candida tropicalis, Candida glabrata, and Cryptococcus neoformans, ravuconazole MICs were greater than or equal to1 mug/ml.
引用
收藏
页码:3107 / 3111
页数:5
相关论文
共 29 条
[1]   In vivo pharmacodynamics of a new triazole, ravulconazole, in a murine candidiasis model [J].
Andes, D ;
Marchillo, K ;
Stamstad, T ;
Conklin, R .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2003, 47 (04) :1193-1199
[2]  
Arikan Sevtap, 2002, Curr Opin Investig Drugs, V3, P555
[3]   Quality control limits for broth microdilution susceptibility tests of ten antifungal agents [J].
Barry, AL ;
Pfaller, MA ;
Brown, SD ;
Espinel-Ingroff, A ;
Ghannoum, MA ;
Knapp, C ;
Rennie, RP ;
Rex, JH ;
Rinaldi, MG .
JOURNAL OF CLINICAL MICROBIOLOGY, 2000, 38 (09) :3457-3459
[4]   Comparison among air pollutants, meteorological conditions and some chemical parameters in the transplanted lichen Usnea amblyoclada [J].
Carreras, HA ;
Pignata, ML .
ENVIRONMENTAL POLLUTION, 2001, 111 (01) :45-52
[5]   Efficacy of ravuconazole in treatment of systemic murine histoplasmosis [J].
Clemons, KV ;
Martinez, M ;
Calderon, L ;
Stevens, DA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (03) :922-924
[6]   Efficacy of ravueonazole in treatment of mucosal candidosis in SCID mice [J].
Clemons, KV ;
Stevens, D .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2001, 45 (12) :3433-3436
[7]   Comparative evaluation of NCCLS M27-A and EUCAST broth microdilution procedures for antifungal susceptibility testing of Candida species [J].
Cuenca-Estrella, M ;
Lee-Yang, W ;
Ciblak, MA ;
Arthington-Skaggs, BA ;
Mellado, E ;
Warnock, DW ;
Rodriguez-Tudela, JL .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (11) :3644-3647
[8]   Activities of caspofungin, itraconazole, posaconazole, ravuconazole, voriconazole, and amphotericin B against 448 recent clinical isolates of filamentous fungi [J].
Diekema, DJ ;
Messer, SA ;
Hollis, RJ ;
Jones, RN ;
Pfaller, MA .
JOURNAL OF CLINICAL MICROBIOLOGY, 2003, 41 (08) :3623-3626
[9]   Testing conditions for determination of minimum fungicidal concentrations of new and established antifungal agents for Aspergillus spp.:: NCCLS Collaborative Study [J].
Espinel-Ingroff, A ;
Fothergill, A ;
Peter, J ;
Rinaldi, MG ;
Walsh, TJ .
JOURNAL OF CLINICAL MICROBIOLOGY, 2002, 40 (09) :3204-3208
[10]   In vitro antifungal activity of BMS-207147 and itraconazole against yeast strains that are non-susceptible to fluconazole [J].
Fung-Tomc, JC ;
White, TC ;
Minassian, B ;
Huczko, E ;
Bonner, DP .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 1999, 35 (02) :163-167