RAID: a comprehensive resource for human RNA-associated (RNA-RNA/RNA-protein) interaction

被引:50
作者
Zhang, Xiaomeng [1 ]
Wu, Deng [1 ]
Chen, Liqun [1 ]
Li, Xiang [1 ]
Yang, Jinxurong [1 ]
Fan, Dandan [1 ]
Dong, Tingting [1 ]
Liu, Mingyue [1 ]
Tan, Puwen [1 ]
Xu, Jintian [1 ]
Yi, Ying [1 ]
Wang, Yuting [1 ]
Zou, Hua [1 ]
Hu, Yongfei [1 ]
Fan, Kaili [1 ]
Kang, Juanjuan [1 ]
Huang, Yan [1 ]
Miao, Zhengqiang [1 ]
Bi, Miaoman [1 ]
Jin, Nana [1 ]
Li, Kongning [1 ]
Li, Xia [1 ]
Xu, Jianzhen [2 ]
Wang, Dong [1 ]
机构
[1] Harbin Med Univ, Coll Bioinformat Sci & Technol, Harbin 150081, Peoples R China
[2] Henan Univ Technol, Coll Bioengn, Zhengzhou 450000, Peoples R China
基金
黑龙江省自然科学基金; 中国博士后科学基金; 中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词
RNA-RNA; RNA-protein; interaction; database; NONCODING RNAS; BINDING SITES; CLIP-SEQ; DATABASE; PREDICTION; CELLS; MICRORNAS; NETWORKS; STARBASE; CERNA;
D O I
10.1261/rna.044776.114
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Transcriptomic analyses have revealed an unexpected complexity in the eukaryote transcriptome, which includes not only protein-coding transcripts but also an expanding catalog of noncoding RNAs (ncRNAs). Diverse coding and noncoding RNAs (ncRNAs) perform functions through interaction with each other in various cellular processes. In this project, we have developed RAID (http://www.rna-society.org/raid), an RNA-associated (RNA-RNA/RNA-protein) interaction database. RAID intends to provide the scientific community with all-in-one resources for efficient browsing and extraction of the RNA-associated interactions in human. This version of RAID contains more than 6100 RNA-associated interactions obtained by manually reviewing more than 2100 published papers, including 4493 RNA RNA interactions and 1619 RNA protein interactions. Each entry contains detailed information on an RNA-associated interaction, including RAID ID, RNA/protein symbol, RNA/protein categories, validated method, expressing tissue, literature references (Pubmed IDs), and detailed functional description. Users can query, browse, analyze, and manipulate RNA-associated (RNA-RNA/RNA-protein) interaction. RAID provides a comprehensive resource of human RNA-associated (RNA-RNA/RNA-protein) interaction network. Furthermore, this resource will help in uncovering the generic organizing principles of cellular function network.
引用
收藏
页码:989 / 993
页数:5
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