A facile synthetic approach to a biodegradable polydisulfide MRI contrast agent

被引:11
作者
Cheng, Weiren [1 ,3 ]
Rajendran, Reshmi [2 ]
Ren, Wei [1 ]
Gu, Liuqun [1 ]
Zhang, Yong [3 ]
Chuang, Kai-Hsiang [2 ]
Liu, Ye [1 ]
机构
[1] ASTAR, Inst Mat Res & Engn, Singapore 117602, Singapore
[2] ASTAR, Singapore Bioimaging Consortium, Singapore 138667, Singapore
[3] Natl Univ Singapore, Dept Biomed Engn, Singapore 117575, Singapore
关键词
MICHAEL ADDITION POLYMERIZATIONS; NEPHROGENIC SYSTEMIC FIBROSIS; DRUG-DELIVERY; GD(III) COMPLEXES; IN-VIVO; TRIFUNCTIONAL AMINES; SILICA VESICLES; GADOLINIUM; ENHANCEMENT; DIAGNOSIS;
D O I
10.1039/c4tb00413b
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
A polydisulfide MRI contrast agent was obtained by grafting diethylenetriaminepentaacetic (DTPA) to disulfide-containing poly(amido amine)s-graft-poly(ethylene glycol) (PEG) followed by Gd(III) complexation. Self-assembly of the MRI contrast agent obtained occurs in aqueous solution forming nanosized micelles with PEG shells and ionic complex cores. The chemistry and structures of the MRI contrast agent and assembly were characterized using NMR, GPC and DLS. Thiol-induced degradation of the backbone and the assembly of the MRI contrast agent were investigated using GPC and DLS, respectively, and easy degradation was observed. Poly(BAC-AMPD)-g-PEG-g-Gd-DTPA also shows a low cytotoxicity and a high r(1) value, so it is promising to provide better MRI imaging with fewer side effects.
引用
收藏
页码:5295 / 5301
页数:7
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