Microbiome and pancreatic cancer: A comprehensive topic review of literature

被引：62
作者：
Ertz-Archambault, Natalie [1 ]
Keim, Paul [2 ,3 ]
Von Hoff, Daniel [4 ]
机构：
[1] Mayo Clin Arizona, Dept Internal Med, Mayo Sch Grad Med Educ, 13400 E Shea Blvd, Scottsdale, AZ 85259 USA
[2] Translat Genom Inst, Pathogen Genom Div, Flagstaff, AZ 86001 USA
[3] Regents Northern Arizona Univ, Flagstaff, AZ 86001 USA
[4] Mayo Clin Arizona, Translat Genom Inst TGen, Scottsdale, AZ 85259 USA
来源：
WORLD JOURNAL OF GASTROENTEROLOGY | 2017年 / 23卷 / 10期
关键词：
Pancreatic Cancer; Human microbiome; Biomarkers; cancer; Cancer screening tests; Treatment effectiveness; HELICOBACTER-PYLORI INFECTION; CYTOTOXIN-ASSOCIATED GENE; PERIODONTAL-DISEASE; RISK-FACTOR; TOOTH LOSS; ASSOCIATION; CACHEXIA; SEROPOSITIVITY; INFLAMMATION; SURVIVAL;
D O I：
10.3748/wjg.v23.i10.1899
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
AIM To review microbiome alterations associated with pancreatic cancer, its potential utility in diagnostics, risk assessment, and influence on disease outcomes. METHODS A comprehensive literature review was conducted by allinclusive topic review from PubMed, MEDLINE, and Web of Science. The last search was performed in October 2016. RESULTS Diverse microbiome alterations exist among several body sites including oral, gut, and pancreatic tissue, in patients with pancreatic cancer compared to healthy populations. CONCLUSION Pilot study successes in non- invasive screening strategies warrant further investigation for future translational application in early diagnostics and learn modifiable risk factors relevant to disease prevention. Pre- clinical investigations exist in other tumor types that suggest microbiome manipulation provides opportunity to favorably transform cancer response to existing treatment protocols and improve survival.
引用
收藏
页码：1899 / 1908
页数：10
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