Risk of Anxiety and Depression in Patients with Inflammatory Bowel Disease: A Nationwide, Population-Based Study

被引:95
作者
Choi, Kookhwan [1 ,2 ]
Chun, Jaeyoung [1 ,2 ,3 ]
Han, Kyungdo [4 ]
Park, Seona [1 ,2 ]
Soh, Hosim [1 ,2 ]
Kim, Jihye [1 ,2 ]
Lee, Jooyoung [1 ,2 ]
Lee, Hyun Jung [1 ,2 ]
Im, Jong Pil [1 ,2 ]
Kim, Joo Sung [1 ,2 ]
机构
[1] Seoul Natl Univ, Coll Med, Dept Internal Med, 101 Daehak Ro, Seoul 110799, South Korea
[2] Seoul Natl Univ, Coll Med, Liver Res Inst, 101 Daehak Ro, Seoul 110799, South Korea
[3] Yonsei Univ, Gangnam Severance Hosp, Dept Internal Med, Coll Med, Seoul 06273, South Korea
[4] Catholic Univ Korea, Coll Med, Dept Med Stat, Seoul 06591, South Korea
关键词
anxiety; claims data; depression; inflammatory bowel disease; STAGE RENAL-DISEASE; MENTAL-DISORDERS; PREVALENCE; KOREA; HEALTH; CANCER; PAIN; EPIDEMIOLOGY; PATHOGENESIS; COMORBIDITY;
D O I
10.3390/jcm8050654
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background and Aims: Inflammatory bowel disease (IBD) may be associated with anxiety and depression. The aim of this study was to evaluate the incidence of anxiety and depression in patients with IBD compared to the general population. Methods: A nationwide population-based cohort study was conducted using claims data from the National Healthcare Insurance service in Korea. We compared the incidence of anxiety and depression between 15,569 IBD patients and 46,707 non-IBD controls, age and sex matched at a ratio of 1:3. Results: During a mean follow-up of six years, IBD patients experienced significantly more anxiety (12.2% vs. 8.7%; p < 0.001) and depression (8.0% vs. 4.7%; p < 0.001) compared to controls. The curves showing cumulative incidences of anxiety and depression showed a steep rise within one year following a diagnosis of IBD, leading to lines with a constant slope. The hazard ratio (HR) for new onset anxiety following a diagnosis of Crohn's disease (CD) and ulcerative colitis (UC) was 1.63 and 1.60, respectively, compared to controls (p < 0.001). Compared to controls, the HR for developing depression after a diagnosis of CD and UC was 2.09 and 2.00, respectively (p < 0.001). The risks of anxiety and depression in patients with IBD were higher compared to controls, except in those with diabetes mellitus, hypertension, and dyslipidemia, or who required immunomodulators and biologics within one year of the IBD diagnosis. Conclusions: The risk of anxiety and depression increased after a diagnosis of IBD compared to the general population.
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页数:14
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共 48 条
[1]   Why is depression more prevalent in women? [J].
Albert, Paul R. .
JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 2015, 40 (04) :219-221
[2]   Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease [J].
Ananthakrishnan, A. N. ;
Gainer, V. S. ;
Perez, R. G. ;
Cai, T. ;
Cheng, S-C. ;
Savova, G. ;
Chen, P. ;
Szolovits, P. ;
Xia, Z. ;
De Jager, P. L. ;
Shaw, S. Y. ;
Churchill, S. ;
Karlson, E. W. ;
Kohane, I. ;
Perlis, R. H. ;
Plenge, R. M. ;
Murphy, S. N. ;
Liao, K. P. .
ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 2013, 37 (04) :445-454
[3]   Depression and anxiety 3 months post stroke: Prevalence and correlates [J].
Barker-Collo, Suzanne L. .
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 2007, 22 (04) :519-531
[4]   Psychological Stress and Depression: Risk Factors for IBD? [J].
Bernstein, Charles N. .
DIGESTIVE DISEASES, 2016, 34 (1-2) :58-63
[5]   Brain-Gut Interactions in Inflammatory Bowel Disease [J].
Bonaz, Bruno L. ;
Bernstein, Charles N. .
GASTROENTEROLOGY, 2013, 144 (01) :36-49
[6]   Prevalence and Correlates of DSM-IV Mental Disorders in South Korean Adults: The Korean Epidemiologic Catchment Area Study 2011 [J].
Cho, Maeng Je ;
Seong, Su Jeong ;
Park, Jee Eun ;
Chung, In-Won ;
Lee, Young Moon ;
Bae, Ahn ;
Ahn, Joon Ho ;
Lee, Dong-Woo ;
Bae, Jae Nam ;
Cho, Seong-Jin ;
Park, Jong-Ik ;
Son, Jungwoo ;
Chang, Sung Man ;
Hahm, Bong-Jin ;
Lee, Jun-Young ;
Sohn, Jee Hoon ;
Kim, Jin Sun ;
Hong, Jin Pyo .
PSYCHIATRY INVESTIGATION, 2015, 12 (02) :164-170
[7]   Temporal trends of the prevalence and incidence of atrial fibrillation and stroke among Asian patients with hypertrophic cardiomyopathy: A nationwide population-based study [J].
Choi, You-Jung ;
Choi, Eue-Keun ;
Han, Kyung-Do ;
Jung, Jin-Hyung ;
Park, Jiesuck ;
Lee, Euijae ;
Choe, Wonseok ;
Lee, So-Ryoung ;
Cha, Myung-Jin ;
Lim, Woo-Hyun ;
Oh, Seil .
INTERNATIONAL JOURNAL OF CARDIOLOGY, 2018, 273 :130-135
[8]  
Feroze U, 2010, IRAN J KIDNEY DIS, V4, P173
[9]   Depression and anxiety levels in therapy-naive patients with inflammatory bowel disease and cancer of the colon [J].
Filipovic, Branislav R. ;
Filipovic, Branka F. ;
Kerkez, Mirko ;
Milinic, Nikola ;
Randelovic, Tomislav .
WORLD JOURNAL OF GASTROENTEROLOGY, 2007, 13 (03) :438-443
[10]   Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota [J].
Galley, Jeffrey D. ;
Nelson, Michael C. ;
Yu, Zhongtang ;
Dowd, Scot E. ;
Walter, Jens ;
Kumar, Purnima S. ;
Lyte, Mark ;
Bailey, Michael T. .
BMC MICROBIOLOGY, 2014, 14