Epilepsies associated with focal cortical dysplasias (FCDs)

被引：47

作者：

Najm, Imad M. ^{[1
]}

Tassi, Laura ^{[2
]}

Sarnat, Harvey B. ^{[3
,4
]}

Holthausen, Hans ^{[5
,6
]}

Lo Russo, Giorgio ^{[2
]}

机构：

[1] Cleveland Clin, Neurol Inst, Epilepsy Ctr, Cleveland, OH 44106 USA

[2] Epilepsy Surg Ctr C, Milan, Italy

[3] Univ Calgary, Fac Med, Dept Paediat, Calgary Res Inst, Calgary, AB, Canada

[4] Alberta Childrens Prov Gen Hosp, Calgary, AB, Canada

[5] Schoen Klin Vogtareuth, Epilepsy Ctr Children & Adolescents, Neuropediat Clin, Vogtareuth, Germany

[6] Schoen Klin Vogtareuth, Epilepsy Ctr Children & Adolescents, Clin Neurorehabil, Vogtareuth, Germany

来源：

ACTA NEUROPATHOLOGICA | 2014年 / 128卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Focal cortical dysplasia; Epilepsy; Mechanisms; Classification; Surgery; Outcome; TEMPORAL-LOBE EPILEPSY; NEURONAL MIGRATION DISORDERS; AMINO-ACID RECEPTORS; HOC TASK-FORCE; SURGICAL-TREATMENT; PRESURGICAL EVALUATION; CLINICAL CORRELATIONS; INTRACTABLE EPILEPSY; DIFFERENTIAL EXPRESSION; GENETIC CLASSIFICATION;

D O I：

10.1007/s00401-014-1304-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Focal cortical dysplasias (FCDs) are increasingly recognized as one of the most common causes of pharmaco-resistant epilepsies. FCDs were recently divided into various clinico-pathological subtypes due to distinct imaging, electrophysiological, and outcome characteristics. In this review, we will overview the international consensus classification of FCDs in light of more recently reported clinical, electrical, imaging and functional observations, and will also address areas of ongoing debate. In addition, we will summarize our current knowledge on pathobiology and epileptogenicity of FCDs as well as its underlying molecular and cellular mechanisms. The clinical (electroencephalographic, imaging, and functional) characteristics of major FCD subtypes and their implications on the presurgical evaluation and surgical management will be discussed in light of studies describing these characteristics and postoperative seizure outcomes in patients with medically intractable focal epilepsy due to histopathologically confirmed FCDs.

引用

页码：5 / 19

页数：15

共 124 条

[71] Surgical resection of focal cortical dysplasias in the central region [J].

Marnet, D. ;

Devaux, B. ;

Chassoux, F. ;

Landre, E. ;

Mann, M. ;

Turak, B. ;

Rodrigo, S. ;

Varlet, P. ;

Daumas-Duport, C. .

NEUROCHIRURGIE, 2008, 54 (03) :399-408

[72] Focal cortical dysplasias in eloquent cortex:: Functional characteristics and correlation with MRI and histopathologic changes [J].

Marusic, P ;

Najm, IM ;

Ying, Z ;

Prayson, R ;

Rona, S ;

Nair, D ;

Hadar, E ;

Kotagal, P ;

Bej, MD ;

Wyllie, E ;

Bingaman, W ;

Lüders, H .

EPILEPSIA, 2002, 43 (01) :27-32

[73] Neurons recorded from pediatric epilepsy surgery patients with cortical dysplasia [J].

Mathern, GW ;

Cepeda, C ;

Hurst, RS ;

Flores-Hernandez, J ;

Mendoza, D ;

Levine, MS .

EPILEPSIA, 2000, 41 :S162-S167

[74] MRI-negative prefrontal epilepsy due to cortical dysplasia explored by stereoelectroencephalography (SEEG) [J].

McGonigal, Aileen ;

Gavaret, Martine ;

Da Fonseca, Agnes Trebuchon ;

Guye, Maxime ;

Scavarda, Didier ;

Villeneuve, Nathalie ;

Regis, Jean ;

Bartolomei, Fabrice ;

Chauvel, Patrick .

EPILEPTIC DISORDERS, 2008, 10 (04) :330-338

[75]

MELDRUM BS, 1992, CURR OPIN NEUROL NEU, V5, P508

[76] INHIBITORY CONTROL OF LOCAL EXCITATORY CIRCUITS IN THE GUINEA-PIG HIPPOCAMPUS [J].

MILES, R ;

WONG, RKS .

JOURNAL OF PHYSIOLOGY-LONDON, 1987, 388 :611-629

[77] The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia [J].

Möddel, G ;

Jacobson, B ;

Ying, Z ;

Janigro, D ;

Bingaman, W ;

González-Martínez, J ;

Kellinghaus, C ;

Prayson, RA ;

Najm, IM .

BRAIN RESEARCH, 2005, 1046 (1-2) :10-23

[78] Chronic subdural electrodes in the management of epilepsy [J].

Nair, Dileep R. ;

Burgess, Richard ;

McIntyre, Cameron C. ;

Lueders, Hans .

CLINICAL NEUROPHYSIOLOGY, 2008, 119 (01) :11-28

[79] Epileptogenicity correlated with increased N-methyl-D-aspartate receptor subunit NR2A/B in human focal cortical dysplasia [J].

Najm, IM ;

Ying, Z ;

Babb, T ;

Mohamed, A ;

Hadam, J ;

LaPresto, E ;

Wyllie, E ;

Kotagal, P ;

Bingaman, W ;

Foldvary, N ;

Morris, H ;

Lüders, HO .

EPILEPSIA, 2000, 41 (08) :971-976

[80] The use of subdural grids in the management of focal malformations due to abnormal cortical development [J].

Najm, IM ;

Bingaman, WE ;

Lüders, HO .

NEUROSURGERY CLINICS OF NORTH AMERICA, 2002, 13 (01) :87-+

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