Epilepsies associated with focal cortical dysplasias (FCDs)

被引：47

作者：

Najm, Imad M. ^{[1
]}

Tassi, Laura ^{[2
]}

Sarnat, Harvey B. ^{[3
,4
]}

Holthausen, Hans ^{[5
,6
]}

Lo Russo, Giorgio ^{[2
]}

机构：

[1] Cleveland Clin, Neurol Inst, Epilepsy Ctr, Cleveland, OH 44106 USA

[2] Epilepsy Surg Ctr C, Milan, Italy

[3] Univ Calgary, Fac Med, Dept Paediat, Calgary Res Inst, Calgary, AB, Canada

[4] Alberta Childrens Prov Gen Hosp, Calgary, AB, Canada

[5] Schoen Klin Vogtareuth, Epilepsy Ctr Children & Adolescents, Neuropediat Clin, Vogtareuth, Germany

[6] Schoen Klin Vogtareuth, Epilepsy Ctr Children & Adolescents, Clin Neurorehabil, Vogtareuth, Germany

来源：

ACTA NEUROPATHOLOGICA | 2014年 / 128卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Focal cortical dysplasia; Epilepsy; Mechanisms; Classification; Surgery; Outcome; TEMPORAL-LOBE EPILEPSY; NEURONAL MIGRATION DISORDERS; AMINO-ACID RECEPTORS; HOC TASK-FORCE; SURGICAL-TREATMENT; PRESURGICAL EVALUATION; CLINICAL CORRELATIONS; INTRACTABLE EPILEPSY; DIFFERENTIAL EXPRESSION; GENETIC CLASSIFICATION;

D O I：

10.1007/s00401-014-1304-0

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Focal cortical dysplasias (FCDs) are increasingly recognized as one of the most common causes of pharmaco-resistant epilepsies. FCDs were recently divided into various clinico-pathological subtypes due to distinct imaging, electrophysiological, and outcome characteristics. In this review, we will overview the international consensus classification of FCDs in light of more recently reported clinical, electrical, imaging and functional observations, and will also address areas of ongoing debate. In addition, we will summarize our current knowledge on pathobiology and epileptogenicity of FCDs as well as its underlying molecular and cellular mechanisms. The clinical (electroencephalographic, imaging, and functional) characteristics of major FCD subtypes and their implications on the presurgical evaluation and surgical management will be discussed in light of studies describing these characteristics and postoperative seizure outcomes in patients with medically intractable focal epilepsy due to histopathologically confirmed FCDs.

引用

页码：5 / 19

页数：15

共 124 条

[61]

Jayakar P, 1994, J Child Neurol, V9 Suppl 2, P61

[62] Epilepsy surgery in children with focal cortical dysplasia (FCD): Results of long-term seizure outcome [J].

Kloss, S ;

Pieper, T ;

Pannek, H ;

Holthausen, H ;

Tuxhorn, I .

NEUROPEDIATRICS, 2002, 33 (01) :21-26

[63] Focal cortical dysplasia: long term seizure outcome after surgical treatment [J].

Kral, T. ;

von Lehe, M. ;

Podlogar, M. ;

Clusmann, H. ;

Sussmann, P. ;

Kurthen, M. ;

Becker, A. ;

Urbach, H. ;

Schramm, J. .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2007, 78 (08) :853-856

[64] Incomplete resection of focal cortical dysplasia is the main predictor of poor postsurgical outcome [J].

Krsek, P. ;

Maton, B. ;

Jayakar, P. ;

Dean, P. ;

Korman, B. ;

Rey, G. ;

Dunoyer, C. ;

Pacheco-Jacome, E. ;

Morrison, G. ;

Ragheb, J. ;

Vinters, H. V. ;

Resnick, T. ;

Duchowny, M. .

NEUROLOGY, 2009, 72 (03) :217-223

[65] Low-grade focal cortical dysplasia is associated with prenatal and perinatal brain injury [J].

Krsek, Pavel ;

Jahodova, Alena ;

Maton, Bruno ;

Jayakar, Prasanna ;

Dean, Patricia ;

Korman, Brandon ;

Rey, Gustavo ;

Dunoyer, Catalina ;

Vinters, Harry V. ;

Resnick, Trevor ;

Duchowny, Michael .

EPILEPSIA, 2010, 51 (12) :2440-2448

[66] Different presurgical characteristics and seizure outcomes in children with focal cortical dysplasia type I or II [J].

Krsek, Pavel ;

Pieper, Tom ;

Karlmeier, Anja ;

Hildebrandt, Michelle ;

Kolodziejczyk, Dieter ;

Winkler, Peter ;

Pauli, Elisabeth ;

Bluemcke, Ingmar ;

Holthausen, Hans .

EPILEPSIA, 2009, 50 (01) :125-137

[67] Pathogenesis and pathology of focal malformations of cortical development and epilepsy [J].

Kuzniecky, RI ;

Barkovich, AJ .

JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 1996, 13 (06) :468-480

[68] Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies [J].

Kwan, Patrick ;

Arzimanoglou, Alexis ;

Berg, Anne T. ;

Brodie, Martin J. ;

Hauser, W. Allen ;

Mathern, Gary ;

Moshe, Solomon L. ;

Perucca, Emilio ;

Wiebe, Samuel ;

French, Jacqueline .

EPILEPSIA, 2010, 51 (06) :1069-1077

[69] SEIZURES WITH ONSET IN THE SENSORIMOTOR FACE AREA - CLINICAL-PATTERNS AND RESULTS OF SURGICAL-TREATMENT IN 20 PATIENTS [J].

LEHMAN, R ;

ANDERMANN, F ;

OLIVIER, A ;

TANDON, PN ;

QUESNEY, LF ;

RASMUSSEN, TB .

EPILEPSIA, 1994, 35 (06) :1117-1124

[70] Developmental neuropathology and impact of perinatal brain damage.: III:: Gray matter lesions of the neocortex [J].

Marín-Padilla, M .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1999, 58 (05) :407-429

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