Association of Vitamin B12, Lactate Dehydrogenase, and Regulation of NF-B in the Mitigation of Sodium Arsenite-Induced ROS Generation in Uterine Tissue by Commercially Available Probiotics

被引：30

作者：

Chattopadhyay, Sandip ^{[1
,2
]}

Khatun, Shamima ^{[1
,2
]}

Maity, Moulima ^{[1
,2
]}

Jana, Suryashis ^{[1
,2
]}

Perveen, Hasina ^{[1
,2
]}

Dash, Moumita ^{[1
,2
]}

Dey, Arindam ^{[1
,2
]}

Jana, Lipi Rani ^{[1
,2
]}

Maity, Pikash Pratim ^{[1
,2
]}

机构：

[1] Vidyasagar Univ, Dept Biomed Lab Sci & Management, Midnapore 721102, W Bengal, India

[2] Vidyasagar Univ, UGC Innovat Dept, Clin Nutr & Dietet Div, Midnapore 721102, W Bengal, India

来源：

PROBIOTICS AND ANTIMICROBIAL PROTEINS | 2019年 / 11卷 / 01期

关键词：

Sodium arsenite; Probiotics; Oxidative stress; Anti-oxidant system; DNA-breakage; INDUCED OXIDATIVE STRESS; LACTIC-ACID BACTERIA; FACTOR-KAPPA-B; HEAVY-METAL; DNA-DAMAGE; SUPEROXIDE-DISMUTASE; EPITHELIAL-CELLS; DRINKING-WATER; RAT MODEL; IN-VIVO;

D O I：

10.1007/s12602-017-9333-3

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Managing arsenic intoxication with conventional metal chelators is a global challenge. The present study demonstrated the therapeutic role of probiotics against arsenic-induced oxidative stress and female reproductive dysfunction. Sodium arsenite-treated (1.0mg/100g body weight) Wistar female rats were followed up by a post-treatment of commercially available probiotic mixture in powder form (0.25mg/100g body weight) orally. Rats that experienced arsenic ingestion showed a significant lessening in the activities of uterine superoxide dismutase (SOD), catalase activities, and the level of non-protein soluble thiol (NPSH) with a concomitant increase in malondialdehyde (MDA) and conjugated dienes (CD). Exposure to arsenic significantly lowered the levels of vitamin B-12 and estradiol. Exposure to arsenic highly expressed the inflammatory marker and transcription factor NF-B. Arsenic-mediated instability of these above parameters was controlled by the probiotics with a rebuilding of better function of anti-oxidant components. Besides its function in regulating endogenous anti-oxidant system, probiotics were able to augment the protection against mutagenic uterine DNA-breakage, necrosis, and ovarian-uterine tissue damages in arsenicated rats.

引用

页码：30 / 42

页数：13

共 116 条

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