High-dose-rate Brachytherapy and Concurrent Chemoradiotherapy Followed by Surgery for Stage Ib-IIb Cervical Cancer: Single Institution Experience

被引：1

作者：

Froebe, Ana ^{[1
]}

Jones, Glenn ^{[2
]}

Bokulic, Tomislav ^{[1
]}

Mrcela, Iva ^{[1
]}

Budanec, Mirjana ^{[1
]}

Murgic, Jure ^{[1
]}

Jaksic, Blanka ^{[1
]}

Prpic, Marin ^{[1
]}

Bolanca, Ante ^{[1
]}

Kusic, Zvonko ^{[1
]}

机构：

[1] Univ Hosp Sestre Milosrdnice, Dept Oncol & Nucl Med, Zagreb 10000, Croatia

[2] Univ Toronto, Credit Valley Hosp, Dept Radiat Oncol, Mississauga, ON L5L 1C6, Canada

来源：

ANTICANCER RESEARCH | 2014年 / 34卷 / 07期

关键词：

Cervical cancer; high-dose-rate brachytherapy; concomitant chemoradiotherapy; surgery; BULKY RESIDUAL DISEASE; RADIATION-THERAPY; UTERINE CERVIX; EXTRAFASCIAL HYSTERECTOMY; CHEMORADIATION THERAPY; ADJUVANT HYSTERECTOMY; PELVIC IRRADIATION; RANDOMIZED-TRIAL; CARCINOMA; RADIOTHERAPY;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: There are still controversies about the benefit of surgery after concurrent radiochemotherapy (CRT) for locally advanced cervical cancer. The aim of this study was to evaluate toxicity, local tumor control and overall survival of surgery after CRT in stage IB-IIB cervical cancer. Patients and Methods: Between 2002 and 2008, 24 patients with stage IB-IIB cervical cancer were treated with external-beam radiotherapy concomitantly with chemotherapy. High-dose rate brachytherapy fractions were given once weekly. Radical hysterectomy was undertaken after a median of 42 days. Results: Overall survival at five years was estimated at 75% (95% confidence interval=52-88%) and sustained thereafter through to 8.9 years. No patient experienced local failure in the surgical bed. Postoperative complications were recorded in two patients. Conclusion: Surgery after CRT in stage IB-IIB cervical cancer is safe and leads to better local control of the disease and overall survival.

引用

页码：3861 / 3866

页数：6

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