Biological markers for anxiety disorders, OCD and PTSD: A consensus statement. Part II: Neurochemistry, neurophysiology and neurocognition

被引：210

作者：

Bandelow, Borwin ^{[1
]}

Baldwin, David ^{[2
]}

Abelli, Marianna ^{[3
]}

Bolea-Alamanac, Blanca ^{[10
]}

Bourin, Michel ^{[5
]}

Chamberlain, Samuel R. ^{[6
,7
,8
]}

Cinosi, Eduardo ^{[9
]}

Davies, Simon ^{[4
,10
]}

Domschke, Katharina ^{[11
]}

Fineberg, Naomi ^{[6
,7
]}

Gruenblatt, Edna ^{[11
,12
,13
,14
,15
]}

Jarema, Marek ^{[16
]}

Kim, Yong-Ku ^{[17
]}

Maron, Eduard ^{[18
,19
,22
]}

Masdrakis, Vasileios ^{[20
]}

Mikova, Olya ^{[21
]}

Nutt, David ^{[22
]}

Pallanti, Stefano ^{[23
]}

Pini, Stefano ^{[3
]}

Stroehle, Andreas ^{[24
]}

Thibaut, Florence ^{[25
]}

Vaghi, Matilde M. ^{[26
,27
]}

Won, Eunsoo ^{[17
]}

Wedekind, Dirk ^{[1
]}

Wichniak, Adam ^{[16
]}

Woolley, Jade ^{[2
]}

Zwanzger, Peter ^{[28
,29
]}

Riederer, Peter ^{[11
]}

机构：

[1] Univ Gottingen, Dept Psychiat & Psychotherapy, von Siebold Str 5, D-37075 Gottingen, Germany

[2] Univ Southampton, Fac Med, Southampton, Hants, England

[3] Univ Pisa, Sect Psychiat, Dept Clin & Expt Med, Pisa, Italy

[4] Univ Toronto, Geriatr Psychiat Div, Ctr Addict & Mental Hlth, Toronto, ON, Canada

[5] Univ Nantes, Neurobiol Anxiety & Mood Disorders, Nantes, France

[6] Hertfordshire Partnership Univ NHS Fdn Trust, Parkway, England

[7] Univ Hertfordshire, Parkway, England

[8] Univ Cambridge, Dept Psychiat, Cambridge, England

[9] Gabriele DAnnunzio Univ, Dept Neurosci Imaging & Clin Sci, Chieti, Italy

[10] Univ Bristol, Acad Unit Psychiat, Sch Social & Community Med, Bristol, Avon, England

[11] Univ Wurzburg, Dept Psychiat Psychosomat & Psychotherapy, Wurzburg, Germany

[12] Univ Zurich, Hosp Psychiat, Dept Child & Adolescent Psychiat & Psychotherapy, Zurich, Switzerland

[13] Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland

[14] Swiss Fed Inst Technol, Zurich, Switzerland

[15] Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland

[16] Inst Psychiat & Neurol, Dept Psychiat 3, Warsaw, Poland

[17] Korea Univ, Coll Med, Dept Psychiat, Seoul, South Korea

[18] North Estonia Med Ctr, Dept Psychiat, Tallinn, Estonia

[19] Univ Tartu, Dept Psychiat, Tartu, Estonia

[20] Univ Athens, Eginit Hosp, Sch Med, Dept Psychiat 1, Athens, Athens, Greece

[21] Fdn Biol Psychiat, Sofia, Bulgaria

[22] Imperial Coll London, Div Brain Sci, Ctr Neuropsychopharmacol, Fac Med,Dept Med, London, England

[23] UC Davis Dept Psychiat & Behav Sci, Sacramento, CA USA

[24] Charite Univ Med Ctr Berlin, Campus Charite Mitte, Dept Psychiat & Psychotherapy, Berlin, Germany

[25] Univ Hosp Cochin, Fac Med Paris Descartes, Paris, France

[26] Univ Cambridge, Dept Psychiat, Cambridge, England

[27] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge, England

[28] Kbo Inn Salzach Klinikum Wasserburg Inn, Wasserburg, Germany

[29] Ludwig Maximilian Univ Munich, Dept Psychiat & Psychotherapy, Munich, Germany

来源：

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY | 2017年 / 18卷 / 03期

关键词：

Anxiety disorders; neuroimaging; genetic; neurochemistry; neurobiology; review; OBSESSIVE-COMPULSIVE DISORDER; POSTTRAUMATIC-STRESS-DISORDER; HEART-RATE-VARIABILITY; NERVE GROWTH-FACTOR; PITUITARY-ADRENAL-AXIS; URINARY FREE CORTISOL; PLATELET SEROTONIN UPTAKE; CORTICOTROPIN-RELEASING HORMONE; COGNITIVE-BEHAVIORAL THERAPY; ATRIAL-NATRIURETIC-PEPTIDE;

D O I：

10.1080/15622975.2016.1190867

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: Biomarkers are defined as anatomical, biochemical or physiological traits that are specific to certain disorders or syndromes. The objective of this paper is to summarise the current knowledge of biomarkers for anxiety disorders, obsessive-compulsive disorder (OCD) and posttraumatic stress disorder (PTSD).Methods: Findings in biomarker research were reviewed by a task force of international experts in the field, consisting of members of the World Federation of Societies for Biological Psychiatry Task Force on Biological Markers and of the European College of Neuropsychopharmacology Anxiety Disorders Research Network.Results: The present article (Part II) summarises findings on potential biomarkers in neurochemistry (neurotransmitters such as serotonin, norepinephrine, dopamine or GABA, neuropeptides such as cholecystokinin, neurokinins, atrial natriuretic peptide, or oxytocin, the HPA axis, neurotrophic factors such as NGF and BDNF, immunology and CO2 hypersensitivity), neurophysiology (EEG, heart rate variability) and neurocognition. The accompanying paper (Part I) focuses on neuroimaging and genetics.Conclusions: Although at present, none of the putative biomarkers is sufficient and specific as a diagnostic tool, an abundance of high quality research has accumulated that should improve our understanding of the neurobiological causes of anxiety disorders, OCD and PTSD.

引用

页码：162 / 214

页数：53

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