Cdx genes, inflammation and the pathogenesis of Barrett's metaplasia

被引：23

作者：

Colleypriest, Benjamin J. ^{[1
]}

Palmer, Rebecca M. ^{[1
]}

Ward, Stephen G. ^{[2
]}

Tosh, David ^{[1
]}

机构：

[1] Univ Bath, Dept Biol & Biochem, Ctr Regenerat Med, Bath BA2 7AY, Avon, England

[2] Univ Bath, Dept Pharm & Pharmacol, Bath BA2 7AY, Avon, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2009年 / 15卷 / 07期

关键词：

TUMOR-NECROSIS-FACTOR; NF-KAPPA-B; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; HOMEODOMAIN PROTEIN CDX2; BILIARY EPITHELIAL-CELLS; INTESTINAL METAPLASIA; SQUAMOUS EPITHELIUM; ABERRANT EXPRESSION; HOMEOBOX GENE; FACTOR-ALPHA;

D O I：

10.1016/j.molmed.2009.05.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metaplasia is the conversion of one cell or tissue type to another and can predispose patients to neoplasia. Perhaps one of the best-known examples of metaplasia is Barrett's metaplasia (BM), a pathological condition in which the distal oesophageal epithelium switches from stratified squamous to intestinal-type columnar epithelium. BM predisposes to oesophageal adenocarcinoma and is the consequence of long-term acid bile reflux. The incidence of BM and oesophageal adenocarcinoma has risen dramatically in recent years. A key event in the pathogenesis of BM is the induction of oesophageal CDX2 expression. Importantly, recent data reveal the molecular mechanisms that link inflammation in the development of Barrett's metaplasia, CDX2 and the progression to cancer. This review highlights the relationship between inflammation, metaplasia and carcinogenesis.

引用

页码：313 / 322

页数：10

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