Trained Immunity in Atherosclerotic Cardiovascular Disease

被引：73

作者：

Flores-Gomez, Daniela ^{[1
,2
]}

Bekkering, Siroon ^{[1
,2
]}

Netea, Mihai G. ^{[1
,2
,3
]}

Riksen, Niels P. ^{[1
,2
]}

机构：

[1] Radboud Univ Nijmegen Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[2] Radboud Univ Nijmegen Med Ctr, Radboud Ctr Mol Life Sci, Nijmegen, Netherlands

[3] Univ Bonn, Dept Immunol & Metab, Life & Med Sci Inst, Bonn, Germany

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2021年 / 41卷 / 01期

基金：

欧盟地平线“2020”; 欧洲研究理事会;

关键词：

atherosclerosis; cardiovascular disease; inflammation; innate immunity; monocyte;

D O I：

10.1161/ATVBAHA.120.314216

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Atherosclerosis is characterized by incessant inflammation in the arterial wall in which monocytes and macrophages play a crucial role. During the past few years, it has been reported that cells from the innate immune system can develop a long-lasting proinflammatory phenotype after brief stimulation not only with microbial products but also endogenous atherogenic stimuli. This persistent hyperactivation of the innate immune system is termed trained immunity and can contribute to the pathophysiology of atherosclerosis. Trained immunity is mediated via epigenetic and metabolic reprogramming and occurs both in mature innate immune cells as well as their bone marrow progenitors. In addition to monocytes, other innate immune and nonimmune cells involved in different stages of atherosclerosis can develop comparable memory characteristics. This mechanism provides exciting novel pharmacological targets that can be used to prevent or treat cardiovascular diseases.

引用

页码：62 / 69

页数：8

共 54 条

[1] Natural Killer Cells: Development, Maturation, and Clinical Utilization [J].

Abel, Alex M. ;

Yang, Chao ;

Thakar, Monica S. ;

Malarkannan, Subramaniam .

FRONTIERS IN IMMUNOLOGY, 2018, 9

[2] Glutaminolysis and Fumarate Accumulation Integrate Immunometabolic and Epigenetic Programs in Trained Immunity [J].

Arts, Rob J. W. ;

Novakovic, Boris ;

ter Horst, Rob ;

Carvalho, Agostinho ;

Bekkering, Siroon ;

Lachmandas, Ekta ;

Rodrigues, Fernando ;

Silvestre, Ricardo ;

Cheng, Shih-Chin ;

Wang, Shuang-Yin ;

Habibi, Ehsan ;

Goncalves, Luis G. ;

Mesquita, Ines ;

Cunha, Cristina ;

van Laarhoven, Arjan ;

van de Veerdonk, Frank L. ;

Williams, David L. ;

van der Meer, Jos W. M. ;

Logie, Colin ;

O'Neill, Luke A. ;

Dinarello, Charles A. ;

Riksen, Niels P. ;

van Crevel, Reinout ;

Clish, Clary ;

Notebaart, Richard A. ;

Joosten, Leo A. B. ;

Stunnenberg, Hendrik G. ;

Xavier, Ramnik J. ;

Netea, Mihai G. .

CELL METABOLISM, 2016, 24 (06) :807-819

[3] Treatment with Statins Does Not Revert Trained Immunity in Patients with Familial Hypercholesterolemia [J].

Bekkering, Siroon ;

Stiekema, Lotte C. A. ;

Moens, Sophie Bernelot ;

Verweij, Simone L. ;

Novakovic, Boris ;

Prange, Koen ;

Versloot, Miranda ;

van Lennep, Jeanine E. Roeters ;

Stunnenberg, Henk ;

de Winther, Menno ;

Stroes, Erik S. G. ;

Joosten, Leo A. B. ;

Netea, Mihai G. ;

Riksen, Niels P. .

CELL METABOLISM, 2019, 30 (01) :1-2

[4] Metabolic Induction of Trained Immunity through the Mevalonate Pathway [J].

Bekkering, Siroon ;

Arts, Rob J. W. ;

Novakovic, Boris ;

Kourtzelis, Ioannis ;

van der Heijden, Charlotte D. C. C. ;

Li, Yang ;

Popa, Calin D. ;

ter Horst, Rob ;

van Tuijl, Julia ;

Netea-Maier, Romana T. ;

de Veerdonk, Frank L. van ;

Chavakis, Triantafyllos ;

Joosten, Leo A. B. ;

van der Meer, Jos W. M. ;

Stunnenberg, Henk ;

Riksen, Niels P. ;

Netea, Mihai G. .

CELL, 2018, 172 (1-2) :135-+

[5] Innate immune cell activation and epigenetic remodeling in symptomatic and asymptomatic atherosclerosis in humans in vivo [J].

Bekkering, Siroon ;

van den Munckhof, Inge ;

Nielen, Tim ;

Lamfers, Evert ;

Dinarello, Charles ;

Rutten, Joost ;

de Graaf, Jacqueline ;

Joosten, Leo A. B. ;

Netea, Mihai G. ;

Gomes, Marc E. R. ;

Riksen, Niels P. .

ATHEROSCLEROSIS, 2016, 254 :228-236

[6] Oxidized Low-Density Lipoprotein Induces Long-Term Proinflammatory Cytokine Production and Foam Cell Formation via Epigenetic Reprogramming of Monocytes [J].

Bekkering, Siroon ;

Quintin, Jessica ;

Joosten, Leo A. B. ;

van der Meer, Jos W. M. ;

Netea, Mihai G. ;

Riksen, Niels P. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2014, 34 (08) :1731-+

[7] Oxidized phospholipids as a unifying theory for lipoprotein(a) and cardiovascular disease [J].

Boffa, Michael B. ;

Koschinsky, Marlys L. .

NATURE REVIEWS CARDIOLOGY, 2019, 16 (05) :305-318

[8] Symptomatic Carotid Atherosclerotic Plaques Are Associated With Increased Infiltration of Natural Killer (NK) Cells and Higher Serum Levels of NK Activating Receptor Ligands [J].

Bonaccorsi, Irene ;

Spinelli, Domenico ;

Cantoni, Claudia ;

Barilla, Chiara ;

Pipito, Narayana ;

De Pasquale, Claudia ;

Oliveri, Daniela ;

Cavaliere, Riccardo ;

Carrega, Paolo ;

Benedetto, Filippo ;

Ferlazzo, Guido .

FRONTIERS IN IMMUNOLOGY, 2019, 10

[9] Natural killer cells in the innate immunity network of atherosclerosis [J].

Bonaccorsi, Irene ;

De Pasquale, Claudia ;

Campana, Stefania ;

Barberi, Chiara ;

Cavaliere, Riccardo ;

Benedetto, Filippo ;

Ferlazzo, Guido .

IMMUNOLOGY LETTERS, 2015, 168 (01) :51-57

[10]

Burnett John R, 2004, Clin Biochem Rev, V25, P2

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