Tailored doxycycline delivery from MCM-41-type silica carriers

被引：29

作者：

Deaconu, Mihaela ^{[1
]}

Nicu, Ioana ^{[2
]}

Tincu, Robert ^{[1
]}

Brezoiu, Ana-Maria ^{[1
]}

Mitran, Raul-Augustin ^{[3
]}

Vasile, Eugeniu ^{[4
]}

Matei, Cristian ^{[1
]}

Berger, Daniela ^{[1
]}

机构：

[1] Univ Politehn Bucuresti, Dept Inorgan Chem Phys Chem & Electrochem, Polizu St 1-7, Bucharest 011061, Romania

[2] Natl Inst Chem Pharmaceut Res & Dev, Vitan Ave 112, Bucharest 031299, Romania

[3] Romanian Acad, Ilie Murgulescu Inst Phys Chem, Splaiul Independentei 202, Bucharest 060021, Romania

[4] Univ Politehn Bucuresti, Dept Oxide Mat Sci & Engn, Polizu St 1-7, Bucharest 011061, Romania

来源：

CHEMICAL PAPERS | 2018年 / 72卷 / 08期

关键词：

Drug delivery systems; Doxycycline; Mesoporous silica; Release kinetics; Functionalized silica; ION-TETRACYCLINE INTERACTIONS; ORDERED MESOPOROUS SILICA; CONTROLLED DRUG-DELIVERY; CONTROLLED-RELEASE; BACTERIAL-RESISTANCE; BIOLOGICAL-FLUIDS; ESCHERICHIA-COLI; NANOPARTICLES; ANTIBIOTICS; OXYTETRACYCLINE;

D O I：

10.1007/s11696-018-0457-z

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Doxycycline, an antibiotic from the tetracycline class with a broad spectrum of activity, was used to prepare drug delivery systems based on pristine and functionalized mesostructured silica supports. MCM-41-type materials with different textural, structural, and surface properties were used to assess their influence on the drug release kinetics. Small- and wide-angle XRD, FTIR spectroscopy and N-2 adsorption/desorption isotherms were used to characterize the carriers before and after doxycycline loading. The drug release experiments were performed in vitro in 0.2 M phosphate buffer solution at 37 A degrees C, and the slowest drug release kinetics was obtained for magnesium-modified MCM-41 carrier. All drug-loaded materials exhibited good antibacterial activity against Klebsiella pneumoniae ATCC 10031 strain, similar to the drug alone.

引用

页码：1869 / 1880

页数：12

共 51 条

[1] Controlled release of Doxycycline from gum acacia/poly(sodium acrylate) microparticles for oral drug delivery [J].

Bajpai, S. K. ;

Jadaun, Mamta ;

Bajpai, M. ;

Jyotishi, Pooja ;

Shah, Farhan Ferooz ;

Tiwari, Seema .

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2017, 104 :1064-1071

[2] Confinement and controlled release of bisphosphonates on ordered mesoporous silica-based materials [J].

Balas, Francisco ;

Manzano, Miguel ;

Horcajada, Patricia ;

Vallet-Regi, Maria .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (25) :8116-8117

[3] Bioactive silica-based nanoparticles stimulate bone-forming osteoblasts, suppress bone-resorbing osteoclasts, and enhance bone mineral density in vivo [J].

Beck, George R., Jr. ;

Ha, Shin-Woo ;

Camalier, Corinne E. ;

Yamaguchi, Masayoshi ;

Li, Yan ;

Lee, Jin-Kyu ;

Weitzmann, M. Neale .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2012, 8 (06) :793-803

[4] Mesostructured silica and aluminosilicate carriers for oxytetracycline delivery systems [J].

Berger, D. ;

Nastase, S. ;

Mitran, R. A. ;

Petrescu, M. ;

Vasile, E. ;

Matei, C. ;

Negreanu-Pirjol, T. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2016, 510 (02) :524-531

[5] The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit [J].

Brodersen, DE ;

Clemons, WM ;

Carter, AP ;

Morgan-Warren, RJ ;

Wimberly, BT ;

Ramakrishnan, V .

CELL, 2000, 103 (07) :1143-1154

[6] Functionalized micelle-templated silicas (MTS) and their use as catalysts for fine chemicals [J].

Brunel, D .

MICROPOROUS AND MESOPOROUS MATERIALS, 1999, 27 (2-3) :329-344

[7] Tailored Silica-Antibiotic Nanoparticles: Overcoming Bacterial Resistance with Low Cytotoxicity [J].

Capeletti, Larissa Brentano ;

de Oliveira, Luciane Franca ;

Goncalves, Kaliandra de Almeida ;

Affonso de Oiveira, Jessica Fernanda ;

Saito, Angela ;

Kobarg, Joerg ;

Zimnoch dos Santos, Joao Henrique ;

Cardoso, Mateus Borba .

LANGMUIR, 2014, 30 (25) :7456-7464

[8] Spectroscopic Investigation of the pH Controlled Inclusion of Doxycycline and Oxytetracycline Antibiotics in Cationic Micelles and Their Magnesium Driven Release [J].

Cesaretti, Alessio ;

Carlotti, Benedetta ;

Gentili, Pier Luigi ;

Clementi, Catia ;

Germani, Raimondo ;

Elisei, Fausto .

JOURNAL OF PHYSICAL CHEMISTRY B, 2014, 118 (29) :8601-8613

[9] Tetracycline antibiotics: Mode of action, applications, molecular biology, and epidemiology of bacterial resistance [J].

Chopra, I ;

Roberts, M .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2001, 65 (02) :232-+

[10] Multifunctional mesoporous silica nanoparticles for cancer-targeted, controlled drug delivery and imaging [J].

de Oliveira Freitas, Luiza Baptista ;

Corgosinho, Laura de Melo ;

Quintao Arantes Faria, Jerusa Araujo ;

dos Santos, Virgilio Mateus ;

Resende, Jarbas Magalhaes ;

Leal, Alexandre Soares ;

Gomes, Dawidson Assis ;

Barros de Sousa, Edesia Martins .

MICROPOROUS AND MESOPOROUS MATERIALS, 2017, 242 :271-283

← 1 2 3 4 5 6 →