Evolution and Spread of Ebola Virus in Liberia, 2014-2015

被引：73

作者：

Ladner, Jason T. ^{[1
]}

Wiley, Michael R. ^{[1
]}

Mate, Suzanne ^{[1
]}

Dudas, Gytis ^{[2
]}

Prieto, Karla ^{[1
]}

Lovett, Sean ^{[1
]}

Nagle, Elyse R. ^{[1
]}

Beitzel, Brett ^{[1
]}

Gilbert, Merle L. ^{[3
]}

Fakoli, Lawrence ^{[4
]}

Diclaro, Joseph W., II ^{[5
]}

Schoepp, Randal J. ^{[6
]}

Fair, Joseph ^{[7
,8
]}

Kuhn, Jens H. ^{[9
]}

Hensley, Lisa E. ^{[9
]}

Park, Daniel J. ^{[10
]}

Sabeti, Pardis C. ^{[10
,11
]}

Rambaut, Andrew ^{[2
,12
,13
]}

Sanchez-Lockhart, Mariano ^{[1
]}

Bolay, Fatorma K. ^{[4
]}

Kugelman, Jeffrey R. ^{[1
]}

Palacios, Gustavo ^{[1
]}

机构：

[1] US Army, Ctr Genome Sci, Med Res Inst Infect Dis, Frederick, MD 21702 USA

[2] Univ Edinburgh, Inst Evolutionary Biol, Ashworth Labs, Edinburgh EH9 3FL, Midlothian, Scotland

[3] US Army, Mol & Translat Sci Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA

[4] Liberian Inst Biomed Res, Charlesville, Liberia

[5] Naval Med Res Unit 3, Cairo 11517, Egypt

[6] US Army, Diagnost Syst Div, Med Res Inst Infect Dis, Frederick, MD 21702 USA

[7] MRI Global, Rockville, MD 20850 USA

[8] Penn State Univ, Huck Inst Life Sci, University Pk, PA 16802 USA

[9] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA

[10] Broad Inst, Cambridge, MA 02142 USA

[11] Harvard Univ, Cambridge, MA 02138 USA

[12] Univ Edinburgh, Ashworth Labs, Ctr Immunol Infect & Evolut, Edinburgh EH9 3FL, Midlothian, Scotland

[13] NIH, Fogarty Int Ctr, Bethesda, MD 20892 USA

来源：

CELL HOST & MICROBE | 2015年 / 18卷 / 06期

关键词：

RAPID RESPONSE; REMOTE AREAS; TRANSMISSION; OUTBREAKS; GUINEA;

D O I：

10.1016/j.chom.2015.11.008

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.

引用

页码：659 / 669

页数：11

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