Synthesis and properties of degradable poly(urethane urea)s to be used for ligament reconstructions

被引：92
作者：
Gisselfält, K [1 ]
Edberg, B [1 ]
Flodin, P [1 ]
机构：
[1] Artimplant AB, R&D Dept, SE-42132 Vastra Frolunda, Sweden
来源：
BIOMACROMOLECULES | 2002年 / 3卷 / 05期
关键词：
D O I：
10.1021/bm025535u
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the present study we describe the synthesis, wet spinning, mechanical testing, and degradation of poly(urethane urea)s (PUURs) intended for clinical use in anterior cruciate ligament (ACL) reconstruction. The effects of soft segment chemical composition and molar mass and the kind of diamine chain extender on the material properties were investigated. It was found that the fibers made of PUUR with polycaprolactone diol (PCL530) as soft segment and MDI/1,3-DAP as hard segment (PCL530-3) have high tensile strength and high modulus and when degraded keep their tensile strength for the time demanded for the application. In conclusion, from a chemical and mechanical point of view PUUR fibers of PCL530-3, ARTELON, are suitable for designing a degradable ACL device.
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页码：951 / 958
页数：8
相关论文
共 39 条
[1]   X-RAY INVESTIGATIONS CONCERNING PHYSICAL STRUCTURE OF CROSSLINKING IN URETHANE ELASTOMERS .3. COMMON STRUCTURE PRINCIPLES FOR EXTENSIONS WITH ALIPHATIC DIAMINES AND DIOLS [J].
BONART, R ;
MORBITZE.L ;
MULLER, EH .
JOURNAL OF MACROMOLECULAR SCIENCE-PHYSICS, 1974, B 9 (03) :447-461
[2]  
BORETOS JW, 1967, SCIENCE, V158, P1941
[3]   MEASUREMENT OF SYNOVIAL FLUID PH IN NORMAL AND ARTHRITIC KNEES [J].
CUMMINGS, NA ;
NORDBY, GL .
ARTHRITIS AND RHEUMATISM, 1966, 9 (01) :47-&
[4]  
Denti M, 1995, Knee Surg Sports Traumatol Arthrosc, V3, P75, DOI 10.1007/BF01552378
[5]   OPTIMIZATION OF EXTRUDED COLLAGEN-FIBERS FOR ACL RECONSTRUCTION [J].
DUNN, MG ;
AVASARALA, PN ;
ZAWADSKY, JP .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH, 1993, 27 (12) :1545-1552
[6]   COMPARISON OF THROMBOGENICITY OF COMMERCIALLY AVAILABLE CATHETERS [J].
DURST, S ;
LESLIE, J ;
MOORE, R ;
AMPLATZ, K .
RADIOLOGY, 1974, 113 (03) :599-600
[7]  
ENGSTROM B, 1993, CLIN ORTHOP RELAT R, P190
[8]  
FARRAR DJ, 1988, J THORAC CARDIOV SUR, V95, P191
[9]  
FEAGIN JA, 1987, CLIN ORTHOP RELAT R, P13
[10]  
FEAGIN JA, 1988, CRUCIAL LIGAMENTS
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