The marriage of biology with nanomaterials has significantly accelerated advancement of biological techniques, profoundly facilitating practical applications in biomedical fields. With unique optical properties (e.g., tunable broad excitation, narrow emission spectra, robust photostability, and high quantum yield), fluorescent quantum dots (QDs) have been reasonably functionalized with controllable interfaces and extensively used as a new class of optical probe in biological researches. In this review, we summarize the recent progress in synthesis and properties of QDs. Moreover, we provide an overview of the outstanding potential of QDs for biomedical research and innovative methods of drug delivery. Specifically, the applications of QDs as novel fluorescent nanomaterials for biomedical sensing and imaging have been detailedly highlighted and discussed. In addition, recent concerns on potential toxicity of QDs are also introduced, ranging from cell researches to animal models.
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Univ London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, EnglandUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Al-Jamal, Wafa T.
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Al-Jamal, Khuloud T.
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Univ London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, EnglandUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Al-Jamal, Khuloud T.
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Tian, Bowen
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Univ London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, EnglandUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Tian, Bowen
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Lacerda, Lara
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Univ London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, EnglandUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Lacerda, Lara
;
Bornans, Paul H.
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Univ Maastricht, Dept Pathol, Electron Microscopy Unit, NL-6229 ER Maastricht, NetherlandsUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Bornans, Paul H.
;
Frederik, Peter M.
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Univ Maastricht, Dept Pathol, Electron Microscopy Unit, NL-6229 ER Maastricht, NetherlandsUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Frederik, Peter M.
;
Kostarelos, Kostas
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Univ London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, EnglandUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
机构:
USN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
George Mason Univ, Coll Sci, Fairfax, VA 22030 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Algar, W. Russ
;
Wegner, David
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Univ Paris 11, Inst Elect Fondamentale, F-91405 Orsay, FranceUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Wegner, David
;
Huston, Alan L.
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USN, Res Lab, Div Opt Sci, Washington, DC 20375 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Huston, Alan L.
;
Blanco-Canosa, Juan B.
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Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Blanco-Canosa, Juan B.
;
Stewart, Michael H.
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USN, Res Lab, Div Opt Sci, Washington, DC 20375 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Stewart, Michael H.
;
Armstrong, Anika
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USN, Res Lab, Div Opt Sci, Washington, DC 20375 USA
Sotera Def Solut, Crofton, MD 21114 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Armstrong, Anika
;
Dawson, Philip E.
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Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Dawson, Philip E.
;
Hildebrandt, Niko
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Univ Paris 11, Inst Elect Fondamentale, F-91405 Orsay, FranceUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Hildebrandt, Niko
;
Medintz, Igor L.
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USN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
机构:
Univ London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, EnglandUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Al-Jamal, Wafa T.
;
Al-Jamal, Khuloud T.
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h-index: 0
机构:
Univ London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, EnglandUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Al-Jamal, Khuloud T.
;
Tian, Bowen
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h-index: 0
机构:
Univ London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, EnglandUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Tian, Bowen
;
Lacerda, Lara
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h-index: 0
机构:
Univ London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, EnglandUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Lacerda, Lara
;
Bornans, Paul H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maastricht, Dept Pathol, Electron Microscopy Unit, NL-6229 ER Maastricht, NetherlandsUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Bornans, Paul H.
;
Frederik, Peter M.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Maastricht, Dept Pathol, Electron Microscopy Unit, NL-6229 ER Maastricht, NetherlandsUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
Frederik, Peter M.
;
Kostarelos, Kostas
论文数: 0引用数: 0
h-index: 0
机构:
Univ London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, EnglandUniv London, Sch Pharm, Ctr Drug Delivery Res, Nanomed Lab, London WC1N 1AX, England
机构:
USN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
George Mason Univ, Coll Sci, Fairfax, VA 22030 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Algar, W. Russ
;
Wegner, David
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 11, Inst Elect Fondamentale, F-91405 Orsay, FranceUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Wegner, David
;
Huston, Alan L.
论文数: 0引用数: 0
h-index: 0
机构:
USN, Res Lab, Div Opt Sci, Washington, DC 20375 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Huston, Alan L.
;
Blanco-Canosa, Juan B.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Blanco-Canosa, Juan B.
;
Stewart, Michael H.
论文数: 0引用数: 0
h-index: 0
机构:
USN, Res Lab, Div Opt Sci, Washington, DC 20375 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Stewart, Michael H.
;
Armstrong, Anika
论文数: 0引用数: 0
h-index: 0
机构:
USN, Res Lab, Div Opt Sci, Washington, DC 20375 USA
Sotera Def Solut, Crofton, MD 21114 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Armstrong, Anika
;
Dawson, Philip E.
论文数: 0引用数: 0
h-index: 0
机构:
Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
Scripps Res Inst, Dept Cell Biol, La Jolla, CA 92037 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Dawson, Philip E.
;
Hildebrandt, Niko
论文数: 0引用数: 0
h-index: 0
机构:
Univ Paris 11, Inst Elect Fondamentale, F-91405 Orsay, FranceUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA
Hildebrandt, Niko
;
Medintz, Igor L.
论文数: 0引用数: 0
h-index: 0
机构:
USN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USAUSN, Res Lab, Ctr Bio Mol Sci & Engn, Washington, DC 20375 USA