Bioengineered FSTL1 Patches Restore Cardiac Function Following Myocardial Infarction

被引：22

作者：

Altekoeester, Ann-Kristin ^{[1
]}

Harvey, Richard P. ^{[1
]}

机构：

[1] Victor Chang Cardiac Res Inst, Darlinghurst, NSW 2010, Australia

来源：

TRENDS IN MOLECULAR MEDICINE | 2015年 / 21卷 / 12期

关键词：

FOLLISTATIN-LIKE; 1; INJURY; HEART;

D O I：

10.1016/j.molmed.2015.10.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Improving the limited ability of the heart to regenerate after infarction is crucial. Researchers now demonstrate that delivery of follistatin-like 1 (FSTL1) into injured hearts via collagen patches stimulates cardiomyocyte proliferation and cardiac functional recovery. These findings highlight the epicardium as a source of novel regenerative factors and biomimetic nanomaterials in cardiac translational medicine.

引用

页码：731 / 733

页数：3

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