Contact dermatitis to topical acne drugs: a review of the literature

被引：36

作者：

Foti, Caterina ^{[1
]}

Romita, Paolo ^{[1
]}

Borghi, Alessandro ^{[2
]}

Angelini, Gianni ^{[1
]}

Bonamonte, Domenico ^{[1
]}

Corazza, Monica ^{[2
]}

机构：

[1] Univ Bari, Dermatol Clin, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy

[2] Univ Ferrara, Dept Med Sci, Unit Dermatol & Infect Dis, I-44100 Ferrara, Italy

来源：

DERMATOLOGIC THERAPY | 2015年 / 28卷 / 05期

关键词：

acne; allergic contact dermatitis; irritant contact dermatitis; BENZOYL PEROXIDE; PROPIONIBACTERIUM-ACNES; VULGARIS; CLINDAMYCIN; SKIN; ISOTRETINOIN; FILAGGRIN; PATHOGENESIS; 0.1-PERCENT; MANAGEMENT;

D O I：

10.1111/dth.12282

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Acne vulgaris is a chronic dermatological disorder that affects the majority of teenagers in the Western world. Topical therapy is widely used to treat mild-moderate acne and is known as well-tolerated thanks to its low systemic toxicity, although associated to skin adverse effects. Acne seems to be associated also to an intrinsic alteration of the epidermal barrier, regarding both the upper and the follicular stratum corneum that promotes the onset of such local side effects. The commonest one is irritant contact dermatitis, an event of frequent observation occurring with erythema, burning, dryness, scaling, and itching, usually characterized by low severity and limited duration. Among topical acne drugs, retinoids are the most irritating ones. Another side effect is allergic contact dermatitis: it is rare and mainly associated to benzoyl peroxide.

引用

页码：323 / 329

页数：7

共 47 条

[1] Topical acne drugs review of clinical properties, systemic exposure, and safety [J].