Brazilian Consortium for the Study on Renal Diseases Associated With COVID-19: A Multicentric Effort to Understand SARS-CoV-2-Related Nephropathy

被引：6

作者：

Teixeira Junior, Antonio Augusto Lima ^{[1
,2
,3
]}

Neves, Precil Diego Miranda de Menezes ^{[4
,5
,6
]}

Lages, Joyce Santos ^{[2
]}

Cunha, Kaile de Araujo ^{[2
,7
]}

Muniz, Monique Pereira Rego ^{[2
,7
]}

Brito, Dyego Jose de Araujo ^{[7
]}

Watanabe, Andreia ^{[4
,5
]}

Watanabe, Elieser Hitoshi ^{[4
,5
]}

Onuchic, Luiz Fernando ^{[4
,5
]}

Nunes, Lucas Lobato Acatauassu ^{[8
]}

Coutinho Filho, Antonio Fernando ^{[9
]}

Barcelos, Flavia Lara ^{[10
]}

Gatto, Giuseppe Cesare ^{[10
]}

Monteiro, Antonio ^{[11
]}

Polido, Diego do Amaral ^{[12
]}

Motta, Douglas Rafanelle Moura de Santana ^{[13
]}

Leite, Thaisa de Oliveira ^{[14
]}

Guedes, Felipe Leite ^{[15
]}

Gomes, Orlando Vieira ^{[16
]}

Valente, Lucila Maria ^{[17
]}

Israel, Karla Cristina Silva Petruccelli ^{[18
]}

Ladchumananandasivam, Francisco Rasiah ^{[19
]}

de Farias, Ligia Cristina Lopes ^{[20
]}

Marques, Igor Denizarde Bacelar ^{[21
]}

Uliano, Gustavo Lemos ^{[22
]}

Maramaldo, Carlos Eduardo Campos ^{[23
]}

Neto, Lidio Goncalves Lima ^{[23
]}

Luchi, Weverton Machado ^{[24
]}

Wanderley, David Campos ^{[25
]}

Araujo, Stanley de Almeida ^{[25
]}

Salgado Filho, Natalino ^{[2
,7
]}

Silva, Gyl Eanes Barros ^{[2
,7
]}

机构：

[1] Univ Sao Paulo PGGEN FMRP USP, Ribeirao Preto Med Sch, Postgrad Program Genet, Ribeirao Preto, Brazil

[2] Fed Univ Maranhao HU UFMA, Univ Hosp, Sao Luis, Maranhao, Brazil

[3] Fed Univ Maranhao HU UFMA, Univ Hosp, Clin Res Ctr CEPEC, Sao Luis, Maranhao, Brazil

[4] Univ Sao Paulo FM USP, Sch Med, Div Nephrol, Sao Paulo, Brazil

[5] Univ Sao Paulo FM USP, Sch Med, Mol Med Discipline, Sao Paulo, Brazil

[6] Oswaldo Cruz German Hosp, Nephrol & Dialysis Ctr, Sao Paulo, Brazil

[7] Fed Univ Maranhao HU UFMA, Univ Hosp, Serv Nephrol, Sao Luis, Maranhao, Brazil

[8] Fed Univ HUJBB UFPA, Univ Hosp Complex, Joao de Barros Barreto Univ Hosp, Belem, Para, Brazil

[9] Dr Raimundo Bezerra Unit Dialysis & Kidney Transp, Crato, Brazil

[10] Univ Brasilia HUB UNB, Univ Hosp Brasilia, Serv Nephrol, Brasilia, DF, Brazil

[11] Fed Univ Mato Grosso HUMAP UFMS, Maria Aparecida Pedrossian Univ Hosp, Campo Grande, MS, Brazil

[12] Fed Univ Grande Dourados HU UFGD, Univ Hosp, Dourados, MS, Brazil

[13] Fed Univ Sergipe HU UFS, Univ Hosp, Serv Nephrol, Aracaju, Brazil

[14] Fed Univ Sergipe HUL UFS, Univ Hosp Lizard, Serv Nephrol, Lagarto, Brazil

[15] Fed Univ Rio Grande Norte HUOL UFRN, Onofre Lopes Univ Hosp, Serv Nephrol, Natal, RN, Brazil

[16] Fed Univ Vale do Sao Francisco HU Univ, Univ Hosp, Petrolina, Brazil

[17] Fed Univ Pernambuco UFPE, Fac Med, Recife, PE, Brazil

[18] Fed Univ Amazonas UFAM, Dept Clin Med, Postgrad Program Trop Med FMT UEA, Manaus, Amazonas, Brazil

[19] Fed Univ Paraiba HULW UFPB, Lauro Wanderley Univ Hosp, Serv Nephrol, Joao Pessoa, Paraiba, Brazil

[20] Hosp Univ Alcides Carneiro HUAC, Med Clin Unit, Campina Grande, Paraiba, Brazil

[21] Fed Univ Piaui HU UFPI, Univ Hosp, Serv Nephrol, Teresina, Brazil

[22] Fed Univ Pelotas HE UFPEL, Sch Hosp, Pelotas, RS, Brazil

[23] Maranhao Univ Ctr CEUMA, Lab Immunol & Microbiol Resp Infect LIMIR, Sao Luis, Maranhao, Brazil

[24] Fed Univ Espirito Santo HUCAM UFES, Cassiano Antonio Moraes Univ Hosp, Serv Nephrol, Vitoria, Brazil

[25] Fed Univ Minas Gerais UFMG, Nephropathol Inst, Belo Horizonte, MG, Brazil

来源：

FRONTIERS IN MEDICINE | 2020年 / 7卷

关键词：

COVID-19; SARS-CoV-2; glomerulopathy; kidney injury; collapsing glomerulopathy; thrombotic microangiopathy;

D O I：

10.3389/fmed.2020.584235

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Kidney involvement appears to be frequent in coronavirus disease 2019 (COVID-19). Despite this, information concerning renal involvement in COVID-19 is still scarce. Several mechanisms appear to be involved in the complex relationship between the virus and the kidney. Also, different morphological patterns have been described in the kidneys of patients with COVID-19. For some authors, however, this association may be just a coincidence. To investigate this issue, we propose assessing renal morphology associated with COVID-19 at the renal pathology reference center of federal university hospitals in Brazil. Data will come from a consortium involving 17 federal university hospitals belonging to Empresa Brasileira de Servicos Hospitalares (EBSERH) network, as well as some state hospitals and an autopsy center. All biopsies will be sent to the referral center for renal pathology of the EBSERH network. The data will include patients who had coronavirus disease, both alive and deceased, with or without pre-existing kidney disease. Kidney biopsies will be analyzed by light, fluorescence, and electron microscopy. Furthermore, immunohistochemical (IHC) staining for various inflammatory cells (i.e., cells expressing CD3, CD20, CD4, CD8, CD138, CD68, and CD57) as well as angiotensin-converting enzyme 2 (ACE2) will be performed on paraffinized tissue sections. In addition to ultrastructural assays, in situ hybridization (ISH), IHC and reverse transcription-polymerase chain reaction (RT-PCR) will be used to detect Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) in renal tissue. For the patients diagnosed with Collapsing Glomerulopathy, peripheral blood will be collected for apolipoprotein L-1 (APOL1) genotyping. For patients with thrombotic microangiopathy, thrombospondin type 1 motif, member 13 (ADAMTS13), antiphospholipid, and complement panel will be performed. The setting of this study is Brazil, which is second behind the United States in highest confirmed cases and deaths. With this complete approach, we hope to help define the spectrum and impact, whether immediate or long-term, of kidney injury caused by SARS-CoV-2.

引用

页数：9

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