Synthesis and antioxidant properties of novel benzimidazole derivatives

被引：91

作者：

Ayhan-Kilcigil, G ^{[1
]}

Kus, C

Çoban, T

Can-Eke, B

Iscan, M

机构：

[1] Ankara Univ, Dept Pharmaceut Chem, Fac Pharm, TR-06100 Ankara, Turkey

[2] Hacettepe Univ, Fac Pharm, Dept Toxicol, TR-06100 Ankara, Turkey

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2004年 / 19卷 / 02期

关键词：

thiosemicarbazides; triazolylbenzimidazoles; antioxidant;

D O I：

10.1080/1475636042000202017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Some novel benzimidazole derivatives carrying thiosemicarbazide and triazole moieties at the N1 position were synthesized and their in vitro effects on rat liver microsomal NADPH-dependent lipid peroxidation (LP) levels determined by measuring the formation of 2-thiobarbituric acid reactive substance. The free radical scavenging properties of the compounds were also examined in vitro by determining the capacity to scavenge superoxide anion formation and the interaction with the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH). The compounds showed a significant effect in the above tests except to scavenge superoxide anion formation.

引用

页码：129 / 135

页数：7

共 37 条

[1]

ABDELRAHMAN AE, 1983, PHARMAZIE, V38, P589

[2] Antioxidant activity of novel indole derivatives and protection of the myocardial damage in rabbits [J].

Andreadou, I ;

Tasouli, A ;

Bofilis, E ;

Chrysselis, M ;

Rekka, E ;

Tsantili-Kakoulidou, A ;

Iliodromitis, E ;

Siatra, T ;

Kremastinos, DT .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2002, 50 (02) :165-168

[3] Synthesis and antimicrobial activity of some new benzimidazole carboxylates and carboxamides [J].

Ayhan-Kilcigil, G ;

Tunçbilek, M ;

Altanlar, N ;

Göker, H .

FARMACO, 1999, 54 (08) :562-565

[4] LIPID PEROXIDE FORMATION IN RAT BRAIN [J].

BISHAYEE, S ;

BALASUBRAMANIAN, AS .

JOURNAL OF NEUROCHEMISTRY, 1971, 18 (06) :909-+

[5] ANTIOXIDANT DETERMINATIONS BY THE USE OF A STABLE FREE RADICAL [J].

BLOIS, MS .

NATURE, 1958, 181 (4617) :1199-1200

[6] 1,3,4-OXADIAZOLE, 1,3,4-THIADIAZOLE, AND 1,2,4-TRIAZOLE ANALOGS OF THE FENAMATES - IN-VITRO INHIBITION OF CYCLOOXYGENASE AND 5-LIPOXYGENASE ACTIVITIES [J].

BOSCHELLI, DH ;

CONNOR, DT ;

BORNEMEIER, DA ;

DYER, RD ;

KENNEDY, JA ;

KUIPERS, PJ ;

OKONKWO, GC ;

SCHRIER, DJ ;

WRIGHT, CD .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (13) :1802-1810

[7] A study on the antioxidant capacities of some benzimidazoles in rat tissues [J].

Can-Eke, B ;

Puskullu, MO ;

Buyukbingol, E ;

Iscan, M .

CHEMICO-BIOLOGICAL INTERACTIONS, 1998, 113 (01) :65-77

[8] SUBSTITUTED 2-(2-HYDROXYPHENYL)BENZIMIDAZOLES AS POTENTIAL AGENTS FOR THE CONTROL OF PERIODONTAL-DISEASES [J].

COBURN, RA ;

CLARK, MT ;

EVANS, RT ;

GENCO, RJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (01) :205-208

[9] INFRA-RED SPECTRA OF SOME 3,4,5-SUBSTITUTED DERIVATIVES OF 1,2,4-TRIAZOLE [J].

DZIEWONSKA, M .

SPECTROCHIMICA ACTA PART A-MOLECULAR SPECTROSCOPY, 1967, A 23 (05) :1195-+

[10]

ELDINE SAS, 1974, PHARMAZIE, V29, P761

← 1 2 3 4 →