Brief Report: Associations Between Self-injurious Behaviors and Abdominal Pain Among Individuals with ASD-Associated Disruptive Mutations

被引：4

作者：

Kurtz-Nelson, Evangeline C. ^{[1
]}

Tham, See Wan ^{[2
,3
]}

Ahlers, Kaitlyn ^{[1
]}

Cho, Daniel ^{[4
]}

Wallace, Arianne S. ^{[1
]}

Eichler, Evan E. ^{[5
,6
]}

Bernier, Raphael A. ^{[1
]}

Earl, Rachel K. ^{[1
]}

机构：

[1] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA

[2] Univ Washington, Dept Anesthesiol & Pain Med, Seattle, WA 98195 USA

[3] Seattle Childrens Res Inst, Seattle, WA USA

[4] Seattle Childrens Autism Ctr, Seattle, WA USA

[5] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

[6] Howard Hughes Med Inst, Seattle, WA USA

来源：

JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2021年 / 51卷 / 09期

关键词：

Autism spectrum disorder; Intellectual disability; Rare genetic disorders; Self-injurious behavior; Abdominal pain; AUTISM SPECTRUM DISORDER; GASTROINTESTINAL SYMPTOMS; RISK-FACTORS; YOUNG BOYS; CHILDREN; PREVALENCE; ADOLESCENTS; PHENOMENOLOGY; INFANTS; ANXIETY;

D O I：

10.1007/s10803-020-04774-z

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040202 ;

摘要：

Self-injurious behaviors (SIB) are elevated in autism spectrum disorder (ASD) and related genetic disorders, but the genetic and biological mechanisms that contribute to SIB in ASD are poorly understood. This study examined rates and predictors of SIB in 112 individuals with disruptive mutations to ASD-risk genes. Current SIB were reported in 30% of participants and associated with poorer cognitive and adaptive skills. History of severe abdominal pain predicted higher rates of SIB and SIB severity after controlling for age and adaptive behavior; individuals with a history of severe abdominal pain were eight times more likely to exhibit SIB than those with no history. Future research is needed to examine associations between genetic risk, pain, and SIB in this population.

引用

页码：3365 / 3373

页数：9

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