Lifespan Extending and Oxidative Stress Resistance Properties of a Leaf Extracts from Anacardium occidentale L. in Caenorhabditis elegans

被引：63

作者：

Duangjan, Chatrawee ^{[1
,2
,3
]}

Rangsinth, Panthakarn ^{[1
,2
,3
]}

Gu, Xiaojie ^{[2
,4
]}

Wink, Michael ^{[2
]}

Tencomnao, Tewin ^{[1
,3
]}

机构：

[1] Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Clin Chem, Grad Program Clin Biochem & Mol Med, Bangkok 10330, Thailand

[2] Heidelberg Univ, Inst Pharm & Mol Biotechnol, Neuenheimer Feld 364, D-69120 Heidelberg, Germany

[3] Chulalongkorn Univ, Fac Allied Hlth Sci, Dept Clin Chem, Age Related Inflammat & Degenerat Res Unit, Bangkok 10330, Thailand

[4] Dalian Jiaotong Univ, Dept Biotechnol, Sch Environm & Chem Engn, Dalian 116028, Peoples R China

来源：

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2019年 / 2019卷

关键词：

Antioxidants; -; Metabolites;

D O I：

10.1155/2019/9012396

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Anacardium occidentale (AO) contains a number of polyphenolic secondary metabolites with antioxidant activity. The objectives of this study were aimed at investigating the roles of AO leaf extracts in antioxidative stress and longevity, as well as their underlying mechanisms, in the Caenorhabditis elegans (C. elegans) model. AO extracts mediated the survival rate of nematodes under oxidative stress by attenuating intracellular reactive oxygen species (ROS) via the DAF-16/FoxO and SKN-1/Nrf-2 signaling pathways. AO extracts stimulated the expression of stress response genes including SOD-3 and GST-4. Moreover, AO extracts exhibited antiaging activities and enhanced longevity. We observed improved pharyngeal pumping function, attenuation of pigment accumulation (lipofuscin), and an increased lifespan of the worms. Collectively, our results demonstrated that AO extracts exerted both oxidative stress resistance and antiaging properties in the C. elegans model and may lead to new agents to benefit humans in the near future.

引用

页数：16

共 39 条

[1] Epigallocatechin Gallate from Green Tea (Camellia sinensis) Increases Lifespan and Stress Resistance in Caenorhabditis elegans [J].