4D offline PET-based treatment verification in scanned ion beam therapy: a phantom study

被引：6
作者：
Kurz, Christopher [1 ,2 ,7 ]
Bauer, Julia [1 ,2 ]
Unholtz, Daniel [1 ,2 ]
Richter, Daniel [3 ,4 ]
Stuetzer, Kristin [5 ,6 ]
Bert, Christoph [3 ,4 ]
Parodi, Katia [1 ,2 ,7 ]
机构：
[1] Univ Heidelberg Hosp, Heidelberg Ion Beam Therapy Ctr, Heidelberg, Germany
[2] Univ Heidelberg Hosp, Dept Radiat Oncol, Heidelberg, Germany
[3] GSI Helmholtzzentrum Schwerionenforsch, Darmstadt, Germany
[4] Univ Klinikum Erlangen, Strahlenklin, Erlangen, Germany
[5] Tech Univ Dresden, Helmholtz Zentrum Dresden Rossendorf, OncoRay Natl Ctr Radiat Res Oncol, Fac Med, D-01062 Dresden, Germany
[6] Tech Univ Dresden, Helmholtz Zentrum Dresden Rossendorf, Univ Hosp Carl Gustav Carus, D-01062 Dresden, Germany
[7] Univ Munich, Dept Med Phys, Munich, Germany
来源：
PHYSICS IN MEDICINE AND BIOLOGY | 2015年 / 60卷 / 16期
关键词：
ion beam therapy; PET-based treatment monitoring; moving targets; POSITRON-EMISSION-TOMOGRAPHY; INITIAL CLINICAL-EXPERIENCE; RESPIRATORY MOTION; SYSTEM; RECONSTRUCTION; PATIENT; RANGE; FLUKA;
D O I：
10.1088/0031-9155/60/16/6227
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
At the Heidelberg Ion-Beam Therapy Center, patient irradiation with scanned proton and carbon ion beams is verified by offline positron emission tomography (PET) imaging: the beta(+)-activity measured within the patient is compared to a prediction calculated on the basis of the treatment planning data in order to identify potential delivery errors. Currently, this monitoring technique is limited to the treatment of static target structures. However, intra-fractional organ motion imposes considerable additional challenges to scanned ion beam radiotherapy. In this work, the feasibility and potential of time-resolved (4D) offline PET-based treatment verification with a commercial full-ring PET/CT (x-ray computed tomography) device are investigated for the first time, based on an experimental campaign with moving phantoms. Motion was monitored during the gated beam delivery as well as the subsequent PET acquisition and was taken into account in the corresponding 4D Monte-Carlo simulations and data evaluation. Under the given experimental conditions, millimeter agreement between the prediction and measurement was found. Dosimetric consequences due to the phantom motion could be reliably identified. The agreement between PET measurement and prediction in the presence of motion was found to be similar as in static reference measurements, thus demonstrating the potential of 4D PET-based treatment verification for future clinical applications.
引用
收藏
页码：6227 / 6246
页数：20
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