Simmondsia chinensis: A rich source of bioactive flavonoids and lignans

被引：11
作者：
Abdel-Mageed, Wael M. [1 ,2 ]
Bayoumi, Soad A. H. [2 ]
Radwan, Awwad A. [3 ]
Salem-Bekhit, Mounir M. [4 ]
Abd-Alrahman, Sherif H. [5 ]
Basudan, Omer A. [1 ]
Sayed, Hanaa M. [2 ]
机构：
[1] King Saud Univ, Coll Pharm, Dept Pharmacognosy, Riyadh 11451, Saudi Arabia
[2] Assiut Univ, Fac Pharm, Dept Pharmacognosy, Assiut 71526, Egypt
[3] King Saud Univ, Fac Pharm, Pharmaceut Technol Ctr, Riyadh 11451, Saudi Arabia
[4] King Saud Univ, Coll Pharm, Dept Pharmaceut, Riyadh 11451, Saudi Arabia
[5] King Saud Univ, Coll Sci, Dept Biochem, Riyadh 11451, Saudi Arabia
来源：
INDUSTRIAL CROPS AND PRODUCTS | 2014年 / 60卷
关键词：
Simmondsia chinensis; Jojoba; Flavonoids; Lignans; Antioxidant; Lipoxygenase inhibitors; GLYCOSIDES; ANTIOXIDANT; WAX; GLUCOSIDES;
D O I：
10.1016/j.indcrop.2014.06.007
中图分类号：
S2 [农业工程];
学科分类号：
0828 ;
摘要：
A radical scavenging guided phytochemical study on the leaf of Simmondsia chinensis afforded ten flavonoids (1-10) and four lignans (11-14). The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. Among isolated compounds, flavonoid aglycones (1-4) showed stronger antioxidant activity than their glycosides (5-10) whilst lignan glycosides (11-14) showed moderate to weak antioxidant activity using DPPH and beta-carotene methods in relation to BHT (positive control). The inhibitory potential against enzyme lipoxygenase was also evaluated for isolated compounds exhibiting variable potency. For flavonoids, glycosides are less potent inhibitors than free aglycones. Quercetin is the most potent inhibitor with an IC50 of 5.6 mu M. Lignoid glycosides exhibited moderate to weak inhibitory effect against lipoxygenase enzyme. Luteolin was used as a positive control in lipoxygenase inhibiting assay. (C) 2014 Elsevier B.V. All rights reserved.
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收藏
页码：99 / 103
页数：5
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