Nagarines A and B, two novel 8,15-seco diterpenoid alkaloids from Aconitum nagarum

被引：13
|
作者：
Yin, Tianpeng [1 ,2 ]
Shu, Yan [1 ]
Zhou, Hao [1 ]
Cai, Le [1 ]
Ding, Zhongtao [1 ]
机构：
[1] Yunnan Univ, Sch Chem Sci & Technol, Funct Mol Anal & Biotransformat Key Lab Univ Yunn, Kunming 650091, Yunnan, Peoples R China
[2] Zunyi Med Univ, Zhuhai Key Lab Fundamental & Appl Res Tradit Chin, Zhuhai Campus, Zhuhai 519041, Peoples R China
来源：
FITOTERAPIA | 2019年 / 135卷
基金：
中国国家自然科学基金;
关键词：
Aconitum nagarum Stapf; Ranunculaceae; Diterpenoid alkaloids; Interleukin-6; NORDITERPENOID ALKALOIDS; ROOTS;
D O I：
10.1016/j.fitote.2019.03.021
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two novel 8,15-seco C-19-diterpenoid alkaloids, nagarines A (1) and B (2), were isolated from the roots of Aconitum nagarum Stapf (Ranunculaceae), a folk herbal medicine used to treat rheumatism and arthritis in Southwestern China, Northern Burma and Northeastern India. They are the first C-19-diterpenoid alkaloids possessing unprecedented opened D ring formed by the cleavage of the bond between C-8 and C-15. Compounds 1 and 2 showed certain inhibition activities of interleukin-6 in LPS-activated RAW 264.7 cells with IC50 values of 72.63 +/- 0.39 mu M and 52.98 +/- 0.50 mu M, respectively.
引用
收藏
页码：1 / 4
页数：4
相关论文
共 34 条
  • [31] Gyalanunines A and B, two new C20-diterpenoid alkaloids from Delphinium gyalanum
    Ye, Mei-Zhen
    Li, Xin-Yu
    Xie, Jiang
    Chen, Lin
    Gao, Feng
    Zhou, Xian-Li
    Huang, Shuai
    TETRAHEDRON LETTERS, 2022, 108
  • [32] Acoapetaludines A-K, C20 and C19-diterpenoid alkaloids from the whole plants of Aconitum apetalum (Huth) B.Fedtsch
    Hu, Zhan-Xing
    An, Qiao
    Tang, Hong-Yu
    Chen, Zheng-Hong
    Aisa, Haji Aker
    Zhang, Yu
    Hao, Xiao-Jiang
    PHYTOCHEMISTRY, 2019, 167
  • [33] Two novel diterpenoid heterodimers, Bisebracteolasins A and B, from Euphorbia ebracteolata Hayata, and the cancer chemotherapeutic potential of Bisebracteolasin A
    Yuan, Wen-Juan
    Ding, Xiao
    Wang, Zhe
    Yang, Bi-Juan
    Li, Xiao-Nian
    Zhang, Yu
    Chen, Duo-Zhi
    Li, Shun-Lin
    Chen, Quan
    Di, Ying-Tong
    Aisa, Haji Akber
    Hao, Xiao-Jiang
    SCIENTIFIC REPORTS, 2017, 7
  • [34] Pegaharmalines A and B, two novel β-carboline alkaloids with unprecedented carbon skeletons from Peganum harmala
    Wang, Kai-Bo
    Yuan, Chun-Mao
    Xue, Chun-Mei
    Li, Da-Hong
    Jing, Yong-Kui
    He, Hong-Ping
    Hao, Xiao-Jiang
    Di, Ying-Tong
    Li, Zhan-Lin
    Hua, Hui-Ming
    RSC ADVANCES, 2014, 4 (96): : 53725 - 53729
1234