Nagarines A and B, two novel 8,15-seco diterpenoid alkaloids from Aconitum nagarum

被引：13
|
作者：
Yin, Tianpeng [1 ,2 ]
Shu, Yan [1 ]
Zhou, Hao [1 ]
Cai, Le [1 ]
Ding, Zhongtao [1 ]
机构：
[1] Yunnan Univ, Sch Chem Sci & Technol, Funct Mol Anal & Biotransformat Key Lab Univ Yunn, Kunming 650091, Yunnan, Peoples R China
[2] Zunyi Med Univ, Zhuhai Key Lab Fundamental & Appl Res Tradit Chin, Zhuhai Campus, Zhuhai 519041, Peoples R China
来源：
FITOTERAPIA | 2019年 / 135卷
基金：
中国国家自然科学基金;
关键词：
Aconitum nagarum Stapf; Ranunculaceae; Diterpenoid alkaloids; Interleukin-6; NORDITERPENOID ALKALOIDS; ROOTS;
D O I：
10.1016/j.fitote.2019.03.021
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two novel 8,15-seco C-19-diterpenoid alkaloids, nagarines A (1) and B (2), were isolated from the roots of Aconitum nagarum Stapf (Ranunculaceae), a folk herbal medicine used to treat rheumatism and arthritis in Southwestern China, Northern Burma and Northeastern India. They are the first C-19-diterpenoid alkaloids possessing unprecedented opened D ring formed by the cleavage of the bond between C-8 and C-15. Compounds 1 and 2 showed certain inhibition activities of interleukin-6 in LPS-activated RAW 264.7 cells with IC50 values of 72.63 +/- 0.39 mu M and 52.98 +/- 0.50 mu M, respectively.
引用
收藏
页码：1 / 4
页数：4
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