Oxidation of β-Ketoamides: The Synthesis of Vicinal Tricarbonyl Amides

被引：24

作者：

Liu, Yueyang ^{[1
]}

Zhang, Zhiguo ^{[1
]}

Wan, Yameng ^{[1
]}

Zhang, Guisheng ^{[1
]}

Li, Zhonglian ^{[1
]}

Bi, Jingjing ^{[1
]}

Ma, Nana ^{[1
]}

Liu, Tongxin ^{[1
]}

Liu, Qingfeng ^{[1
]}

机构：

[1] Henan Normal Univ, Sch Chem & Chem Engn, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Henna Key Lab Green Chem Media & React,Minist Edu, Xinxiang 453007, Henan, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 07期

关键词：

ELASTASE INHIBITORS YM-47141; ALPHA-HYDROXYLATION; FACILE SYNTHESIS; CHEMISTRY; COMPOUND;

D O I：

10.1021/acs.joc.6b03062

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile and direct oxidative reaction for the synthesis of vicinal tricarbonyl articles in moderate to excellent yields (53-88%) was developed starting from readily available beta-ketoamides in the presence of phenyliodine(III) bis-(trifluoroacetate). The resulting products possess significant synthetic potential, making this approach a valuable addition to the group of traditional methods already available for the preparation of these molecules.

引用

页码：3901 / 3907

页数：7

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