Immunogenicity of a Live Attenuated Chimeric Japanese Encephalitis Vaccine as a Booster Dose After Primary Vaccination With Live Attenuated SA14-14-2 Vaccine A Phase IV Study in Thai Children

被引：5

作者：

Sricharoenchai, Sirintip ^{[1
]}

Lapphra, Keswadee ^{[1
]}

Chuenkitmongkol, Sunate ^{[2
]}

Phongsamart, Wanatpreeya ^{[1
]}

Bouckenooghe, Alain ^{[3
]}

Wittawatmongkol, Orasri ^{[1
]}

Rungmaitree, Supattra ^{[1
]}

Chokephaibulkit, Kulkanya ^{[1
]}

机构：

[1] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Pediat, 2 Wanglang Rd, Bangkok 10700, Thailand

[2] Sanofi Pasteur, Bangkok, Thailand

[3] Sanofi Pasteur, Clin Sci, Singapore, Singapore

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2017年 / 36卷 / 02期

关键词：

booster; CD JEVAX; children; IMOJEV; live attenuated Japanese encephalitis vaccine; VIRUS-VACCINE; SAFETY;

D O I：

10.1097/INF.0000000000001395

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This single-group study investigated the immunogenicity and safety of a booster dose of the recently licensed live attenuated chimeric Japanese encephalitis vaccine in 50 healthy children (1-5 years old) who were primed with the live attenuated SA14-14-2 vaccine. A strong anamnestic response was induced 28 days postbooster: geometric mean titer, 9144 (95% confidence interval: 7365-11353); and seroprotection rate, 49 of 49 (100%) children.

引用

页码：E45 / E47

页数：3

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