Immunogenicity of a Live Attenuated Chimeric Japanese Encephalitis Vaccine as a Booster Dose After Primary Vaccination With Live Attenuated SA14-14-2 Vaccine A Phase IV Study in Thai Children

被引:5
作者
Sricharoenchai, Sirintip [1 ]
Lapphra, Keswadee [1 ]
Chuenkitmongkol, Sunate [2 ]
Phongsamart, Wanatpreeya [1 ]
Bouckenooghe, Alain [3 ]
Wittawatmongkol, Orasri [1 ]
Rungmaitree, Supattra [1 ]
Chokephaibulkit, Kulkanya [1 ]
机构
[1] Mahidol Univ, Siriraj Hosp, Fac Med, Dept Pediat, 2 Wanglang Rd, Bangkok 10700, Thailand
[2] Sanofi Pasteur, Bangkok, Thailand
[3] Sanofi Pasteur, Clin Sci, Singapore, Singapore
关键词
booster; CD JEVAX; children; IMOJEV; live attenuated Japanese encephalitis vaccine; VIRUS-VACCINE; SAFETY;
D O I
10.1097/INF.0000000000001395
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This single-group study investigated the immunogenicity and safety of a booster dose of the recently licensed live attenuated chimeric Japanese encephalitis vaccine in 50 healthy children (1-5 years old) who were primed with the live attenuated SA14-14-2 vaccine. A strong anamnestic response was induced 28 days postbooster: geometric mean titer, 9144 (95% confidence interval: 7365-11353); and seroprotection rate, 49 of 49 (100%) children.
引用
收藏
页码:E45 / E47
页数:3
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