Gold-Catalyzed Intermolecular Reactions of (Z)-Enynols with Indoles for the Construction of Dihydrocyclohepta[b]indole Skeletons through a Cascade Friedel-Crafts/Hydroarylation Sequence

被引：107
作者：
Lu, Yuhua [1 ,2 ]
Du, Xiangwei [1 ]
Jia, Xueshun [2 ]
Liu, Yuanhong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China
[2] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 10期
基金：
中国国家自然科学基金;
关键词：
enynols; Friedel-Crafts reaction; gold catalysis; hydroarylation; indoles; MARINE ALKALOID CAULERSIN; EFFICIENT SYNTHESIS; HOMOGENEOUS CATALYSIS; UNACTIVATED OLEFINS; ORGANIC-SYNTHESIS; HIGHLY EFFICIENT; CYCLIZATION; ALCOHOLS; ALKYNES; (Z)-2-EN-4-YN-1-OLS;
D O I：
10.1002/adsc.200900068
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An efficient domino approach for the synthesis of indole-fused carbocycles and their analogues from the reactions of suitably substituted (Z)-enynols with indoles or pyrroles under mild reaction conditions was developed. This methodology is realized by a tandem reaction using Au/Ag catalysts, which could catalyze both of the Friedel-Crafts and the hydroarylation reaction in the same vessel.
引用
收藏
页码：1517 / 1522
页数：6
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